Method for preparing sulfachloropyrazine sodium solution serving as compound anti-coccidium medicine

A technology of sulfachlorpyrazine sodium and drug solution, which is used in drug delivery, drug combination, anti-infective drugs and other directions

Active Publication Date: 2015-02-25
QINGDAO VLAND BIOTECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] 3. In the state of disease or stress in chickens, there is often a phenomenon of decreased feed intake or no food, but generally drinking water is normal, so the premix cannot play its medicinal role well

Method used

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  • Method for preparing sulfachloropyrazine sodium solution serving as compound anti-coccidium medicine
  • Method for preparing sulfachloropyrazine sodium solution serving as compound anti-coccidium medicine
  • Method for preparing sulfachloropyrazine sodium solution serving as compound anti-coccidium medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Accurately weigh 30kg of dimethyl sulfoxide, 40kg of N-methylpyrrolidone and 10kg of sulfachlorpyrazine sodium and pour them into the liquid mixing tank at room temperature and stir until dissolved. Mix 2kg of ditrimethoprim with 10kg of glacial acetic acid and dissolve at low temperature , pour the above solution, and finally adjust the pH value (7) with triethanolamine, and set the volume to 100kg with N-methylpyrrolidone. The medicinal solution is then filtered through a 0.45 μm microporous filter element, and then sterilized at 100° C. for 30 minutes to obtain the product.

Embodiment 2

[0055] Accurately weigh 35kg of dimethyl sulfoxide, 30kg of N-methylpyrrolidone and 15kg of sulfachlorpyrazine sodium, pour them into the liquid mixing tank and stir at room temperature until dissolved, mix 3kg of ditrimethoprim with 5kg of lactic acid and dissolve at a low temperature. Pour the above solution, and finally adjust the pH value (6.5) with triethanolamine, and set the volume to 100kg with N-methylpyrrolidone. The medicinal solution is then filtered through a 0.45 μm microporous filter element, and then sterilized at 100° C. for 30 minutes to obtain the product.

Embodiment 3

[0057] Accurately weigh 30 kg of dimethyl sulfoxide, 50 kg of N-methylpyrrolidone and 5 kg of sulfachlorpyrazine sodium and pour them into the liquid mixing tank and stir at room temperature until dissolved, then add 2 kg of trimethoprim dissolved in 15 kg of glacial acetic acid, Finally, adjust the pH value (8.0) with triethanolamine, and set the volume to 100kg with N-methylpyrrolidone. The medicinal solution is then filtered through a 0.45 μm microporous filter element, and then sterilized at 100° C. for 30 minutes to obtain the product.

[0058] The invention has the advantages of simple production process, stable product quality, and can be placed at room temperature for two years without deterioration. The medicine is a solution, which is more convenient to administer and divide doses than the existing dispersant, and is especially suitable for large-scale breeding plants, and can greatly reduce the labor intensity of people when administering medicine.

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Abstract

The invention relates to a method for preparing a sulfachloropyrazine sodium and diaveridine solution serving as a compound efficient anti-coccidium medicine and mainly overcomes defects that prior powders are difficult to mix uniformly, inconvenient to dose, inaccurate in administration dosage and the like. Components of the sulfachloropyrazine sodium solution comprise main drugs of sulfachloropyrazine sodium and diaveridine and auxiliary materials of dimethyl sulfoxide, N-methyl-2-pyrrolidone, a cosolvent and triethanolamine. The method includes pouring the dimethyl sulfoxide, the N-methyl-2-pyrrolidone and the sulfachloropyrazine sodium into a liquid tank to be dissolved, adding the diaveridine which is dissolved by the cosolvent, and finally adding the triethanolamine with amount of formula. The method has the advantages that the production process is simple, the product quality is stable, the medicated operation is simple, and the dosage is accurate.

Description

technical field [0001] The invention relates to a preparation method of a compound high-efficiency anticoccidial medicine sulfachlorpyrazine sodium and trimethoprim solution. Background technique [0002] Sulfachlorpyrazine sodium, a sulfonamide drug, chemically named N-(5-chloro-3-pyrazinyl)-4-aminobenzenesulfonamide sodium salt monohydrate, molecular weight 324.72, molecular formula C 10 h 8 ClN 4 NaO 2 S·H 2 O, white or light yellow powder; odorless. Soluble in water or methanol, slightly soluble in ethanol or acetone, insoluble in chloroform. [0003] Dimethoprim, an antibacterial synergist, chemical name is 5-(3,4-dimethoxybenzyl)-2,4-pyrimidinediamine, molecular weight 260.29, molecular formula C 13 h 16 N 4 o 2 , white or slightly yellow crystalline powder; almost odorless. Very slightly soluble in chloroform, insoluble in water, ethanol or ether; soluble in hydrochloric acid, slightly soluble in dilute hydrochloric acid. Fat-water partition coefficient Log...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/635A61K31/505A61K9/08A61P33/02
Inventor 郝智慧栾明娜贾德强刘元元冯培生张瑞丽王艳玲沈巍
Owner QINGDAO VLAND BIOTECH INC
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