Wake-time-extending agent

A time extension and time technology, applied in food preparation, food science, application, etc., to achieve the effect of prolonging awakening time, shortening sleep time, and high safety

Inactive Publication Date: 2013-02-13
MEIJI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] However, since the circadian rhythm normalizing composition described in Patent Document 7 is a composition that affects sleep time, it is questionable whether it can improve poor sleep quality due to a low amount of exercise during active hours.
Furthermore, astaxanthin, which is a circadian rhythm normalizing composition described in Patent Document 7, belongs to marine carotenoids, and when it is applied to food and beverages such as dairy products, for example, the peculiar smell from raw materials becomes a problem, and it remains a problem in terms of flavor. question

Method used

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Examples

Experimental program
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Effect test

experiment example 1

[0096]

[0097] Under pentobarbital anesthesia, the heads of eight 10-week-old male SD rats were incised, and an electroencephalogram transmitter (Data Science) was implanted on the top of the cranium. Thereafter, the rats were normally bred for 3 weeks, and rats with no problem in general condition were used for the experiment. They were divided into two groups: a control group (3 rats) and a lutein-administered group (3 rats). Suspend Lutein 20S (20% by mass of lutein, Kyowa Fermentation Bio, reddish-brown heat-softening paste containing 20% ​​of lutein derived from marigold petals) that is 20% lutein in olive oil , at 16:00, the dose of 80 mg / kg (16 mg / kg in terms of lutein) was orally administered to rats. Olive oil was orally administered to the control group at the same time. Afterwards, within 16 hours from 17:00 to 9:00 the next day, including 2 hours before and after the dark period (19:00 to 7:00) which is the time zone of the rat's activity, the rats were measur...

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Abstract

Disclosed is a food, beverage or medicinal material which is safe and readily available, does not undergo the deterioration in flavor when combined with another food material or material, is suitably applicable to foods, beverages and medicinal agents, and has a wake-time-extending activity. It is found that an oxidized carotene derivative derived from a terrestrial animal, a terrestrial plant or a microorganism has an activity of shortening a sleep time and extending a wake time.

Description

technical field [0001] The present invention relates to an awakening time prolonging agent which uses carotene oxidized derivatives derived from terrestrial animals, terrestrial plants or microorganisms as active ingredients. Background technique [0002] Carotenoids are a general term for hydrocarbon carotenoids composed of 8 isoprenoid units. Carotenoids are distributed in plants, microorganisms, and animals as natural pigments, and include substances that have physiological effects in the form of provitamin A such as β-carotene, active ingredients of crude drugs such as crocetin and crocetin, And substances containing these substances are important as food coloring materials. In addition, in plants and photosynthetic bacteria, it is known as an auxiliary enzyme in phototransmission (Non-Patent Document 1). In addition, recently, among carotenoids, carotenoids contained in marine organisms such as fish and shellfish and seaweed, ie, so-called marine carotenoids, have dis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/047A23L1/30A61K45/00A61P25/20
CPCA23V2002/00A23L1/30A23L1/3002A23L33/10A23L33/105A61P25/00A61P25/20A23V2250/211A23V2200/31
Inventor 内田胜幸山田成臣伊藤裕之
Owner MEIJI CO LTD
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