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Lanceleaf anisetree extract and external transdermal absorption agent containing lanceleaf anisetree extract

A transdermal absorption preparation, the technology of red fennel, which is applied in the direction of medical preparations containing active ingredients, anti-inflammatory agents, skin diseases, etc., can solve the problems of inconvenient use and toxicity, and achieve convenient use, low cost and long-lasting drug effect Effect

Active Publication Date: 2013-02-27
陈剑美
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, apart from the occasional powder, wine orally or externally used to treat the above diseases, Taikang Pharmaceutical currently exclusively produces red fennel injection. Since the injection is a high-risk preparation, it has certain toxicity and is inconvenient to use.

Method used

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  • Lanceleaf anisetree extract and external transdermal absorption agent containing lanceleaf anisetree extract
  • Lanceleaf anisetree extract and external transdermal absorption agent containing lanceleaf anisetree extract
  • Lanceleaf anisetree extract and external transdermal absorption agent containing lanceleaf anisetree extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1 red fennel extract

[0028] Red fennel root bark coarse powder (12~20 mesh) 200~400g, soak for 48 hours in ethanol with 75% concentration of 2 times the amount of medicinal materials, percolate, collect 4 times the amount of medicinal materials as primary liquid, and store separately; continue Collect the medicinal liquid of 4 times the amount of the medicinal material as the subsequent ethanol, decompress and reclaim the ethanol in the subsequent ethanol, concentrate to dryness, and transfer the concentrated dry paste of the obtained secondary eluent to the initial eluent, and obtain the red fennel extract. The ratio of medicine to liquid is 1:4.

Embodiment 2

[0029] Embodiment 2 red fennel extract

[0030] Red fennel stem bark coarse powder (12~20 mesh) 400g, soak for 36 hours in 85% ethanol with 3 times the amount of medicinal materials, percolate, collect 5 times the medicinal liquid as the primary liquid, save it separately; continue to collect medicinal materials 5 times the amount of the liquid medicine is the follow-up liquid, and the ethanol in the follow-up liquid is recovered under reduced pressure, concentrated to dryness, and the concentrated dry paste of the obtained follow-up liquid is transferred to the initial wash liquid, and the obtained red fennel extract liquid is The ratio is 1:5.

Embodiment 3

[0031] Embodiment 3 red fennel aerosol

[0032] (1) Preparation of red fennel extract:

[0033] Red fennel root bark coarse powder (12~20 mesh) 200g, soak for 48 hours in 75% ethanol with 2 times the amount of medicinal materials, and percolate, collect 4 times the medicinal liquid as the primary liquid, and save it separately; continue to collect medicinal materials 4 times the amount of the liquid medicine is the follow-up liquid, and the ethanol in the follow-up liquid is recovered under reduced pressure, concentrated to dryness, and the concentrated dry paste of the obtained follow-up liquid is transferred to the initial wash liquid, and the obtained red fennel extract liquid is The ratio is 1:4.

[0034] (2) Red fennel aerosol formula: Take 200ml of the above-mentioned red fennel extract, 30mL of glycerin, 6g of ethyl cellulose, 15mL of azone, 15g of borneol, 15mL of peppermint oil, and add 75% ethanol to 1000mL.

[0035] Preparation method: Add 30mL of glycerin, 6g of ...

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Abstract

The invention discloses a lanceleaf anisetree extract and an external transdermal absorption agent containing the lanceleaf anisetree extract. The lanceleaf anisetree extract is prepared by the following steps of immersing the lanceleaf anisetree root bark or stem bark coarse powder in alcohol of which the quantity is 2 to 3 times of the quantity of the lanceleaf anisetree root bark or stem bark coarse powder and the concentration is 70% to 90%, percolating, collecting the medicine liquor of which the quantity is 3 to 5 times of the quantity of the medicine as a primary percolating liquid, and separately storing; continuously collecting the medicine liquor of which the quantity is 4 to 5 times of the quantity of the medicine as a continuous percolating liquid, depressurizing to recover alcohol, concentrating into dry paste, dissolving the concentrated dry paste of continuous percolating liquid into the primary percolating liquid, and then obtaining the the medicine liquor of the lanceleaf anisetree extract with the ratio of 1:3-5. The lanceleaf anisetree extract is added with auxiliary materials to be prepared into external transdermal absorption agents, such as aerosols, gels and emplastrum. The agents have the functions of swelling relieving, stasis eliminating, blood activating and pain relieving, and are used for traumatic injury and rheumatic arthritis, the therapeutic transdermal absorption rate is high for skin diseases, such as eczema, dermatitis and herpes zoster, the therapeutic effect is good, the convenience in use is realized for patients, the preparation is convenient, and the safety is high.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to an extract of red fennel and an external transdermal absorption preparation containing the extract of red fennel. Background technique [0002] Red fennel is the dry root or stem bark of Lllicium lanceolatum A.C Smith, Magnoliaceae. It has the effects of reducing swelling, dispersing blood stasis, promoting blood circulation and relieving pain. It can be used for the treatment of bruises and rheumatoid arthritis. At present, apart from the occasional powder, wine orally or externally used to treat the above diseases, Taikang Pharmaceutical currently exclusively produces red fennel injection. Since the injection is a high-risk preparation, it has certain toxicity and is inconvenient to use. [0003] At present, there is an urgent need for a red fennel extract with good curative effect, high safety and convenience and its external transdermal absorption prepa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/57A61K9/12A61K9/06A61K9/70A61P29/00A61P19/02A61P17/00
Inventor 王曙东
Owner 陈剑美
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