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Application of geniposide in preparation of medicine for treating fatty liver disease

A technology of geniposide and fatty liver, which is applied in the field of application of geniposide in the preparation of drugs for the treatment of fatty liver, and can solve the problems that have not yet been reported on the treatment of fatty liver by geniposide

Inactive Publication Date: 2013-03-13
XIAMEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Geniposide is an iridoid glycoside compound, synonymously known as geniposide, prunin glucoside deshydroxygeniposide, which has the functions of promoting choleresis, protecting the liver, lowering blood pressure, preventing and treating atherosclerosis, antithrombotic, and sedative , analgesic, antipyretic, anti-inflammatory, anti-microbial, etc., but there is no report on the treatment of fatty liver with geniposide

Method used

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  • Application of geniposide in preparation of medicine for treating fatty liver disease
  • Application of geniposide in preparation of medicine for treating fatty liver disease
  • Application of geniposide in preparation of medicine for treating fatty liver disease

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Embodiment Construction

[0013] In order to better understand the essence of the present invention, the experimental results of geniposide against fatty liver in golden hamsters are used below to illustrate the effect of geniposide in treating fatty liver.

[0014] 1 material

[0015] 1.1 Experimental animals SD male golden hamsters, 18, clean grade, about 100g, were provided by the Shanghai Experimental Animal Center of the Chinese Academy of Sciences.

[0016] 1.2 Drugs and reagents Geniposide was provided by Nanjing Zelang Biotechnology Co., Ltd. TG kits, ALT kits, and AST kits were purchased from Nanjing Jiancheng Bioengineering Institute.

[0017] 1.3 High-fat feed Composition of high-fat feed: 83.25% basic feed, 10% lard, 1.5% cholesterol, 0.2% sodium deoxycholate, 5% sugar, 0.05% propylthiouracil, provided by Suzhou Shuangshi Animal Feed Co., Ltd. .

[0018] 2 methods

[0019] 2.1 Modeling and Grouping Drugs From the day of modeling, according to the random number table, the golden hamsters ...

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Abstract

The invention provides application of geniposide in preparation of a medicine for treating fatty liver disease, and relates to novel application of the geniposide. The geniposide can be used for preparing the medicine for treating fatty liver disease. The medicine can be prepared into commonly used clinical preparation according to conventional method, and the oral solid preparation is better, such as granule, tablet and capsule. The medicine contains 50 to 100mg / kg of geniposide by weight. The medicine is subjected to the test on high fat diet-induced golden hamster with fatty liver disease; and as the test shown, the medicine can obviously reduce the contents of serum TG (Triacylglycerol) and the content of liver tissue TG, and inhibit the raise of the activity of serum ALT (Glutamic-Pyruvic Transaminase) and AST (Glutamic Oxalacetic Transaminase), and has the effect of treating the fatty liver disease, so that the geniposide can be used for preparing the medicine for treating the fatty liver disease.

Description

technical field [0001] The invention relates to a new application of geniposide, in particular to the application of geniposide in the preparation of medicaments for treating fatty liver. Background technique [0002] In recent years, with the changes in dietary structure and lifestyle, the incidence of fatty liver in my country has been increasing and tends to be younger. As an important factor in the occurrence and development of chronic liver diseases such as liver fibrosis, cirrhosis, and liver cancer, it is very likely to become The number one liver disease in China. Strengthening the study of this disease is an important measure to reduce and prevent the progress of chronic liver disease, which has important social and economic significance. At present, traditional Chinese medicine compound has become an important means of treating fatty liver, but it is difficult to be accepted by modern medicine because of its complex composition. However, there are still few litera...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P1/16
Inventor 陈少东周海虹
Owner XIAMEN UNIV
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