A compound liver-protecting traditional Chinese medicine for treating non-alcoholic fatty liver

A non-alcoholic and fatty liver technology, applied in the field of compound liver-protecting traditional Chinese medicine for the treatment of non-alcoholic fatty liver, can solve the problems of reducing absorption, increasing carotenoid absorption, etc. Effects of side effects
CN105030816BInactive Publication Date: 2018-02-09QINGDAO MUNICIPAL HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
QINGDAO MUNICIPAL HOSPITAL
Publication Date
2018-02-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a compound liver-protecting traditional Chinese medicine for treating non-alcoholic fatty liver, which comprises the following components in parts by weight: 2-10 parts by weight of chitosan oligosaccharide, 3-20 parts by weight of salidroside, 5-10 parts by weight of resveratrol, 10-20 parts by weight of astaxanthin and 5-15 parts by weight of sea cucumber glycosaminoglycan. In the present invention, through in vivo and in vitro experiments on NAFLD mouse models, five bioactive components of salidroside, chitosan, resveratrol, chitosan and sea cucumber glycosaminoglycans have been determined by cell and molecular biology methods. After the scientific proportioning, it can regulate the genes related to lipid metabolism, significantly reduce the content of triglyceride in NAFLD liver cells, reduce the apoptosis induced by fatty acids, reduce the hepatic steatosis of high-fat diet mice, and reduce the intrahepatic TG content, and no obvious side effects, no cytotoxicity, will not destroy the body's own immune balance.
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Description

technical field

[0001] The invention belongs to the technical field of medicines, and in particular relates to a compound liver-protecting traditional Chinese medicine for treating non-alcoholic fatty liver. technical background

[0002] Nonalcoholic fatty liver disease (NAFLD) is a clinicopathological syndrome characterized by steatosis, necrosis, inflammatory cell infiltration, and fat accumulation in hepatic parenchymal cells. Fatty liver (NAFL), steatohepatitis (NASH) and related cirrhosis. Nonalcoholic fatty liver disease has become the leading cause of chronic liver disease in western developed countries. In my country, NAFLD is the second most common liver disease after chronic viral hepatitis. The pathogenesis of NAFLD is very complex, mostly caused by factors such as obesity, diabetes, hyperlipidemia, insulin resistance and metabolic disorder syndrome affecting liver fat metabolism. NAFLD can coexist with other chronic liver diseases, and can exacerbate liver dam...

Claims

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