Medical application of MAGL inhibitor

A technology of MAGLII-11, 1.MAGLII-11, which is applied in the field of preparation of drugs for the prevention or treatment of alcoholic fatty liver disease, and can solve problems such as high price and damage to liver function

Pending Publication Date: 2022-07-26
SHANDONG NEWTIME PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, many blood lipid-lowering drugs can promote blood lipids to be more concentrated in the liver for metabolism, which may instead promote the accumulation of lipids in the liver and further damage liver function; and these drugs need to be taken for a long time and are expensive

Method used

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  • Medical application of MAGL inhibitor
  • Medical application of MAGL inhibitor
  • Medical application of MAGL inhibitor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1 Effect of compound MAGLⅡ-11 on alcoholic fatty liver

[0035] SD rats, 72, weighing 180-220g, half male and half male, were randomly divided into 9 groups, namely control group, model group, JZL184 group, MAGLⅡ-2 group, MAGLⅡ-10 group, MAGLⅡ-17 group, MAGLⅡ-11 group Low dose group, MAGLⅡ-11 medium dose group, MAGLⅡ-11 high dose group.

[0036] The control group was given normal saline by gavage and fed with normal feed; the rest of the rats were given free access to 10% alcohol and fed high-nutrient feed (normal feed supplemented with 10% whole milk powder, 10% egg yolk powder, 10% refined lard, etc.) after 6 weeks , divided into model group and each administration group, continued to feed high-nutrition feed and drink 10% alcohol for 4 weeks, and at the same time began to give drugs or distilled water by gavage for 4 weeks. 24 hours after the last administration, the orbits were bled, the serum was separated, and the serum liver function was measured; the an...

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PUM

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Abstract

The invention relates to application of MAGLII-11 in preparation of a medicine for preventing or treating alcoholic fatty liver, and belongs to the field of medicine. The invention aims to provide application of the compound in preparation of medicines for preventing or treating alcoholic fatty liver, and the compound is good in treatment effect and high in safety. The MAGLII-11 has a remarkable treatment effect on alcoholic fatty liver, can reduce ALT and AST, reduce TG content, TC content and LDL-C content and improve serum HDL-C content, has remarkable lipid-lowering and liver-protecting effects, and has a remarkable medical prospect.

Description

technical field [0001] The invention belongs to the field of medicine and relates to the use of a MAGL inhibitor in preparing a medicine for preventing or treating alcoholic fatty liver disease. Background technique [0002] Alcoholic liver disease (Alcoholic Hepatitis) is a liver disease caused by long-term heavy drinking. The initial stage is usually fatty liver, which can progress to alcoholic hepatitis, liver fibrosis and cirrhosis. [0003] The clinical manifestations of alcoholic fatty liver disease are proportional to the degree of fatty infiltration of the liver, which disappears after the excess fat in the liver is removed. Clinically, hepatomegaly is the most common sign, followed by liver pain and tenderness. A small number of patients may have mild jaundice, and laboratory tests suggest that it is related to obstruction of the biliary system. Severely ill patients may have ascites and lower extremity edema, and occasionally splenomegaly. Some patients may be ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/445A61P1/16A61P3/06
CPCA61K31/445A61P1/16A61P3/06
Inventor 卢小艳李市荣
Owner SHANDONG NEWTIME PHARMA
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