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Amlodipine besylate medicinal preparation and preparation method thereof

A technology for amlodipine besylate and pharmaceutical preparations, which are applied in the field of amlodipine besylate pharmaceutical preparations and their preparation, can solve the problems of difficulty in measurement and control of mixture parameters, increased costs, and high equipment requirements, and achieve the selection of excipients. Fewer varieties, lower production costs, and better efficacy

Inactive Publication Date: 2013-03-27
KAMP PHARMA
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

[0005] Chinese patent ZL200610116971.8 discloses a preparation process of amlodipine besylate tablets. The process for preparing amlodipine besylate tablets is simple, but it is difficult to measure and control the parameters of the mixture during the preparation process. The method requires high equipment, which increases the production cost of the enterprise

Method used

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  • Amlodipine besylate medicinal preparation and preparation method thereof

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Embodiment

[0032] prescription:

[0033] Amlodipine Besylate 50g

[0034] Dicalcium Phosphate Anhydrous 394g

[0035] Microcrystalline Cellulose 776g

[0036] Carboxymethyl Starch Sodium 25g

[0037] 0.5% aqueous solution of sodium carboxymethylcellulose appropriate amount

[0038] Magnesium stearate 13 g

[0039]

[0040] A total of 10,000 pieces were made

[0041] Preparation:

[0042] First, the raw and auxiliary materials are sieved with a 100-mesh sieve. Said amlodipine besylate according to the prescription amount, added microcrystalline cellulose of equal weight and mixed twice by the method of equal increase, added remaining microcrystalline cellulose, calcium hydrogen phosphate anhydrous, sodium starch glycolate, fully mixed for 5 Minutes, add an appropriate amount of 0.5% aqueous solution of sodium carboxymethylcellulose to make a soft material. Inspect the quality of soft materials: knead them into balls, rub them and loosen them. Take the above soft material ...

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Abstract

The invention discloses an amlodipine besylate medicinal preparation and a preparation method thereof. An amlodipine besylate tablet with stable main drug content and high bioavailability is prepared by reasonable matching of main and auxiliary materials. The method disclosed by the invention is simple and convenient in technological operation, low in device requirement, low in production cost, and suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a pharmaceutical preparation of amlodipine besylate and a preparation method thereof. Background technique [0002] In recent years, with the improvement of people's living standards, the incidence of hypertension has also been increasing, and high blood pressure can cause damage to the heart, brain, kidneys and other human organs, which in turn lead to cardiovascular diseases. According to surveys, cardiovascular diseases It has become one of the frequent diseases that endanger human health. Research and development of a drug that can effectively treat hypertension has always been the unremitting pursuit of scholars at home and abroad. [0003] Amlodipine besylate is a third-generation 1,4-dihydropyridine calcium ion antagonist successfully developed by Pfizer Pharmaceuticals Co., Ltd. in the mid-1980s. It has mild and long-lasting effects, is convenient to take, and h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/4422A61P9/12
Inventor 曾培安吴健民姜勇张静贺莲刘娟
Owner KAMP PHARMA
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