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Application of chloroquine and chlorpromazine to preparation of drug for treating and preventing lung infection and injury

A technology for chlorpromazine, lung infection, applied in the direction of medical preparations containing active ingredients, respiratory diseases, organic active ingredients, etc.

Inactive Publication Date: 2013-04-10
THE INST OF BASIC MEDICAL SCI OF CHINESE ACAD OF MEDICAL SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Chloroquine, chlorpromazine and derivatives thereof are used separately or in combination for the treatment and / or prevention of influenza at present.

Method used

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  • Application of chloroquine and chlorpromazine to preparation of drug for treating and preventing lung infection and injury
  • Application of chloroquine and chlorpromazine to preparation of drug for treating and preventing lung infection and injury
  • Application of chloroquine and chlorpromazine to preparation of drug for treating and preventing lung infection and injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1: Chloroquine, chlorpromazine reduce H5N1 type avian influenza virus infection and cause mouse death rate

[0035] Experimental Materials:

[0036] 1) Main experimental instruments: three-level biosafety laboratory, three-level biological safety cabinet, animal breeding cabinet, mouse breeding cage, small animal surgical instruments, sterile syringes, pipettes, pipettes, etc.

[0037] 2) Main experimental reagents: chloroquine (C6628, purchased from Sigma-Aldrich Company), chlorpromazine (C8138, purchased from Sigma-Aldrich Company), solvent control is PBS, 1% (W / V) pentobarbital sodium solution , virus dilution, disinfectant (2.5% iodine and 75% alcohol), etc.

[0038] 3) Virus: H5N1 avian influenza virus A / Jilin / 9 / 2004 (H5N1)

[0039] 4) Experimental animals:

[0040] SPF grade wild-type (WT) BALB / c mice (4 weeks old): purchased from China National Institute for the Control of Pharmaceutical and Biological Products.

[0041] experimental method:

[00...

Embodiment 2

[0053] Example 2 Chloroquine and chlorpromazine alleviate the pulmonary edema of mice after H5N1 type avian influenza virus infection

[0054] Experimental Materials:

[0055] 1) Main experimental instruments: three-level biosafety laboratory, three-level biological safety cabinet, animal breeding cabinet, mouse breeding cage, small animal surgical instruments, sterile syringes, pipettes, pipettes, etc.

[0056] 2) Main experimental reagents: chloroquine (C6628, purchased from Sigma-Aldrich Company), chlorpromazine (C8138, purchased from Sigma-Aldrich Company), solvent control is PBS, 1% (W / V) pentobarbital sodium solution , virus dilution, disinfectant (2.5% iodine and 75% alcohol), etc.

[0057] 3) Virus: H5N1 avian influenza virus A / Jilin / 9 / 2004 (H5N1)

[0058] 4) Experimental animals: SPF grade wild-type (WT) BALB / C mice (4 weeks old): purchased from China Institute for the Control of Pharmaceutical and Biological Products.

[0059] experimental method:

[0060] 1) Gro...

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PUM

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Abstract

The invention relates to application of chloroquine and chlorpromazine to preparation of drugs for treating and preventing lung infection and injuries, in particular to application of the chloroquine, the chlorpromazine, derivatives of the chloroquine and the chlorpromazine, mixture of the chloroquine and the chlorpromazine, and drug compositions containing the chloroquine or the chlorpromazine to the preparation of drugs for treating and / preventing lung infection and injuries caused by influenza viruses to mammals including human.

Description

technical field [0001] The present invention relates to the use of chloroquine or chlorpromazine or their derivatives or their mixture in the preparation of medicines for treating and / or preventing lung infection and / or lung injury in mammals including humans caused by influenza virus. Background technique [0002] Influenza virus, referred to as influenza virus, is divided into three types: A, B, and C, which are spherical or filamentous, with a diameter of 80-120nm. The three types of viruses have similar biochemical and biological characteristics. Cold RNA virus. Taxonomically, influenza viruses belong to the family Orthomyxoviridae, which can cause acute upper respiratory tract infections and spread rapidly through the air. There are often periodic pandemics around the world. Influenza viruses can cause severe symptoms such as pneumonia or heart and lung failure in the elderly and children with weak immunity and some patients with immune disorders. [0003] Influenza A...

Claims

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Application Information

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IPC IPC(8): A61K31/5415A61K31/4706A61P31/16A61P11/00
CPCA61K31/5513A61K31/5415A61K9/08A61K31/541A61K31/4706A61P11/00A61P31/16A61K2300/00
Inventor 蒋澄宇金宁一孙阳邹镇李霄闫毅武
Owner THE INST OF BASIC MEDICAL SCI OF CHINESE ACAD OF MEDICAL SCI
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