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Traditional Chinese medicine for treating forepart hepetocirrhosis and preparation method thereof

A technology of traditional Chinese medicine and medicinal materials, applied in the field of medicine, can solve problems such as excessive care, lack of effective pharmacological and clinical research, and difficulty in achieving treatment goals

Inactive Publication Date: 2014-08-06
LIUZHOU HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The first two treatment methods are more individualized, lack effective pharmacological and clinical research, the curative effect is uncertain, and the reproducibility is poor
In terms of Chinese patent medicines, a series of special prescriptions and special medicines have emerged in recent years, such as Qianggan Ruanjian Decoction, Danqi Hegan Granules, Compound 861, Fuzheng Huayu Formula, Compound Biejiaruangan Tablets, Compound Danshen Dripping Pills, Soothing the Liver Lipi Tablets, etc., are mostly made of capsules, tablets or granules with prescriptions such as soothing the liver and regulating qi, promoting blood circulation to remove blood stasis, softening and resolving hard masses, etc., which are convenient to take and have a certain curative effect. Too much sparing, or too much aggressiveness, can achieve a certain clinical effect, but it is still difficult to achieve a satisfactory treatment goal.

Method used

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  • Traditional Chinese medicine for treating forepart hepetocirrhosis and preparation method thereof
  • Traditional Chinese medicine for treating forepart hepetocirrhosis and preparation method thereof
  • Traditional Chinese medicine for treating forepart hepetocirrhosis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Evodia 200g Angelica 500g Paeoniae Alba 500g Chuanxiong 500g

[0064] Codonopsis 500g Guizhi 500g Donkey-hide gelatin 500g Moutan bark 200g

[0065] Ginger 200g Licorice 500g French pinellia 200g Ophiopogon japonicus 500g

[0066] Bupleurum 200g, Citrus aurantium 200g, Poria cocos 500g.

[0067] Take all 15 medicinal materials, add water to extract twice, add 45600g of water for the first time, extract for 1 hour, add 45600g of water for the second time, extract for 1 hour; combine the extracts, concentrate to 80 °C when the relative density is 1.22 paste, add ethanol until the volume percentage concentration of alcohol content is 50%, stir evenly, let it stand for 12 hours, filter, and concentrate the filtrate to an extract with a relative density of 1.25 at 80°C to obtain the active ingredient.

Embodiment 2

[0069] Evodia 800g Angelica 1500g Paeoniae Alba 1500g Chuanxiong 1500g

[0070] Codonopsis 1500g Guizhi 1500g Donkey-hide gelatin 1500g Moutan bark 800g

[0071] Ginger 800g Licorice 1500g French pinellia 800g Ophiopogon japonicus 1500g

[0072] Bupleurum 800g Citrus aurantium 800g Poria cocos 1500g

[0073] Take all 15 medicinal materials, add water to extract twice, add 219600g of water for the first time, extract for 3 hours, add 219600g of water for the second time, extract for 3 hours; combine the extracts, concentrate to 80 °C when the relative density is 1.30. Paste, add ethanol until the volume percentage concentration of alcohol content is 60%, stir evenly, let it stand for 24 hours, filter, and concentrate the filtrate to an extract with a relative density of 1.35 at 80°C to obtain the active ingredient.

[0074] The active ingredient is mixed with appropriate amount of starch and dextrin, granulated, dried and compressed to obtain the tablet of the present inventi...

Embodiment 3

[0076] Evodia 700g Angelica 600g Paeoniae Alba 600g Chuanxiong 600g

[0077] Codonopsis 800g Guizhi 700g Donkey-hide gelatin 600g Moutan bark 700g

[0078] Ginger 700g Licorice 800g French pinellia 700g Ophiopogon japonicus 500g

[0079] Bupleurum 700g, Citrus aurantium 700g, Poria cocos 600g.

[0080] Take all 15 medicinal materials, add water to extract twice, add 90000g of water for the first time, extract for 1.5 hours, add 100000g of water for the second time, extract for 2 hours; combine the extracts, concentrate to 80 °C when the relative density is 1.22 Paste, add ethanol until the volume percentage concentration of alcohol content is 58%, stir evenly, let it stand for 16 hours, filter, and concentrate the filtrate to an extract with a relative density of 1.32 at 80°C to obtain the active ingredient.

[0081] The active ingredient is mixed with an appropriate amount of sucrose and preservatives, and water is added to 10000g to obtain the oral liquid of the present in...

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PUM

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Abstract

The object of the present invention is to provide a kind of traditional Chinese medicine for the treatment of early liver cirrhosis and its preparation method. , Bupleurum, Citrus aurantium, Poria cocos. The present invention uses evodia and cinnamon twig to warm yang and dispel cold; uses angelica, chuanxiong, Moutan cortex, white peony root and donkey-hide gelatin to regulate blood and promote blood stasis; Moisturizing. The medicine of the present invention is matched rationally, cold and heat are used together, attack and tonic are both applied, and both specimens are taken into account, so as to achieve the purpose of softening the liver and transforming stagnation. The traditional Chinese medicine for treating early liver cirrhosis provided by the invention has good effect in treating early liver cirrhosis, no adverse reaction is found, and is safe and reliable.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a traditional Chinese medicine for treating early liver cirrhosis and a preparation method thereof. Background technique [0002] Liver cirrhosis is a common clinical chronic and progressive liver disease, which is diffuse liver damage caused by long-term and repeated effects of one or more causes. Liver fibrosis is the basis of liver cirrhosis. The main pathogenesis of liver cirrhosis is progressive fibrosis. The interstitial collagen (types I and III) of normal liver tissue is mainly distributed in the portal area and around the central vein. In liver cirrhosis, type I and type III collagens are significantly increased and deposited everywhere in the lobules. With the continuous deposition of collagen in the sinusoidal space, the fenestration of endothelial cells is significantly reduced, and the hepatic sinusoids gradually evolve into capillaries, resulting in the obstacle of materi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61P1/16A61K35/36
Inventor 周晓玲谢胜陈峭侯秋科
Owner LIUZHOU HOSPITAL OF TRADITIONAL CHINESE MEDICINE