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PH response micro pump based on micro-fluidic chip and preparation method thereof

A technology of microfluidic chips and micropumps, applied in chemical instruments and methods, laboratory containers, laboratory utensils, etc., to achieve the effects of cost reduction, good application prospects, and simple operation

Inactive Publication Date: 2013-04-24
SUZHOU WENHAO MICROFLUIDIC TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, it is difficult for conventional technologies to intelligently drive microfluids in microchannels. Therefore, it is necessary to develop a convenient, fast, and High-efficiency and low-cost microfluidic drive technology should be one of the research directions of micropumps on microfluidic chips, and there has been no substantial breakthrough yet

Method used

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  • PH response micro pump based on micro-fluidic chip and preparation method thereof

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Effect test

Embodiment 1

[0022] The microstructure and microchannel pattern of the two-layer chip of the microfluidic chip with controllable microfluidic flow are designed and drawn by computer-aided design software. The microstructure and microchannel of the two-layer polymethyl methacrylate (PMMA) chip were processed and prepared by the numerical control CNC system. The chips of each layer were cleaned with tap water and distilled water respectively, and the remaining fingerprints, oil stains and other stains on the surface of the chip were wiped with ethanol. On the double-sided adhesive film, the required microstructures and microchannels were processed with a cutting machine. The two-layer chip is carefully aligned, glued, and pressure-sealed to form a smart micropump based on a microfluidic chip. The sample solution is added to the injection hole of the microfluidic chip, and the solution enters the microchannel driven by an external peristaltic pump. In the micropump area of ​​the microchannel,...

Embodiment 2

[0024] The microstructure and microchannel graphics of the two-layer chip of the centrifugal microfluidic chip were designed and drawn by computer-aided design software. The microstructure and microchannel of the two-layer disc-shaped polycarbonate (PC) chip were processed and prepared by the numerical control CNC system. The chips of each layer were cleaned with tap water and distilled water respectively, and the remaining fingerprints, oil stains and other stains on the surface of the chip were wiped with ethanol. On the double-sided adhesive film, the required microstructures and microchannels were processed with a cutting machine. The two-layer chip is carefully aligned, glued, and pressure-sealed to form a smart micropump based on a microfluidic chip. The sample solution is added to the injection hole of the microfluidic chip, and the solution enters the microchannel driven by an external peristaltic pump. In the micropump area of ​​the microchannel, the surface responds ...

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Abstract

The invention relates to a pH response micro pump based on a micro-fluidic chip and a preparation method thereof. A micro-structure and a micro-channel are formed on the surface of the micro-fluidic chip; the surface of the micro-channel is modified through a pH responsiveness molecule; the change of surface wettability is caused by reversible change of surface appearance and chemical configuration of the micro-channel under the stimulation of different pHs; the motion of micro fluid on the surface of the micro-channel is controlled to realize the intelligent micro pump for controlling the flowing of the micro fluid; and the pH response micro pump is mainly applied to the relevant fields of electrophoretic separation, chromatographic separation, immunoassay and the like. The pH response micro pump and the preparation method thereof have the benefits that the intelligent driving of the micro fluid is realized, the driving cost of the micro fluid is greatly reduced, the pH response micro pump has the characteristics of convenience in carrying, economy, quickness and high efficiency, and a brand-new micro pump technology is provided for the driving of the micro fluid.

Description

technical field [0001] The invention relates to a pH response micropump based on a microfluidic chip and a preparation method thereof. The surface of the microfluidic chip has microstructures and microchannels, and the surface of the microchannels is modified by pH responsive molecules, and stimulated at different pHs. Under the circumstances, the reversible change of the surface morphology and chemical configuration of the microchannel leads to the change of the surface wettability, and controls the movement of the microfluid on the surface of the microchannel, so as to realize the intelligent micropump that controls the flow of the microfluid, which is mainly used in electrophoresis. Separation, chromatographic separation, immunoassay and other related fields. Background technique [0002] As a new type of analysis platform, microfluidic analysis chip has the advantages of miniaturization, automation, integration, convenience and speed, and has been widely used in many fie...

Claims

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Application Information

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IPC IPC(8): B01L3/00
Inventor 聂富强沙俊王晓东叶嘉明
Owner SUZHOU WENHAO MICROFLUIDIC TECH CO LTD
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