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Composition with anticancer effect

A composition and material technology, applied in the field of joint application of deoxyglucose and anti-tumor compounds, capable of solving problems such as increased toxicity of normal cells

Inactive Publication Date: 2015-01-28
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the activity of the modified ursolic acid derivatives has been improved, but the toxicity to normal cells has also increased accordingly

Method used

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  • Composition with anticancer effect
  • Composition with anticancer effect
  • Composition with anticancer effect

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] An in vitro activity test of the anticancer composition on Hep G2 cells is provided, and normal liver cancer cell L02 is provided as a control test.

[0026] In Vitro Anticancer Activity of Ursolic Acid Derivatives USW-006, 2-DG and Their Combinations--MTT Assay of Antiproliferative Effects of Drugs on Hep G2 Cells

[0027] ① Take a bottle of Hep G2 cells in the logarithmic growth phase, digest with trypsin, and make 1×10 4 cells / mL of cell suspension.

[0028] ② Transfer the cell suspension into a 96-well plate, 100 ? 2 Incubate for 24 h in the incubator.

[0029] ③ Divide 2-DG into 5 groups of 10mmol / L, 20mmol / L, 40mmol / L, 60mmol / L and 80mmol / L according to the concentration; divide USW-006 into 1μmol / L, 2μmol / L, 4μmol / L according to the concentration , 6μmol / L, 8μmol / L and 10μmol / L; the combination group was divided into 10mmol / L 2-DG combined with 2μmol / L USW-006, 20mmol / L 2-DG combined with 4μmol / L USW-006, 40mmol / L 2-DG combined with 6μmol / L USW-006, 60mmol / L ...

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Abstract

The invention provides a composition with an anticancer effect, and the composition mainly comprises the following active components: 2-eeoxy-D-glucose and ursolic acid derivatives. The composition can effectively increase the concentration of active drugs on a tumor site, effectively kill hepatoma carcinoma cells and reduce the toxicity and side effect on normal cells, so that the integral effect for treating the tumor can be improved, and a promising application prospect in treating the solid tumor can be realized.

Description

technical field [0001] The invention relates to a composition with anticancer effect, in particular to the combined application of tumor targeting deoxyglucose and antitumor compounds. Background technique [0002] Selective killing of tumor cells while mitigating damage to normal tissues is a major challenge for current cancer treatment strategies. Different from normal cells, even under aerobic conditions, tumor cells mainly decompose glucose and gain energy through glycolysis, and the higher the degree of malignancy of the tumor, the more obvious the characteristics of glycolysis. Therefore, targeting tumor cells with abnormal glucose metabolism may become a new strategy for selectively killing tumor cells. Glycolysis inhibitors are used to block the progress of glycolysis, so that tumor cells die due to lack of energy supply, but normal cells are not affected. [0003] Ursolic acid (Ursolic acid, UA), a terpenoid compound, has a relative molecular weight of 456.68 and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7004A61K31/58A61K31/56A61P35/00A61P1/16A61P35/04
Inventor 邵敬伟李园芳王继闯
Owner FUZHOU UNIV