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Apparatus and method for investigating molecule

A device, a technique of plasmon resonance, used in the study of molecules

Inactive Publication Date: 2013-05-08
BASE4 INNOVATION LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, although nanotechnology has found utility in, for example, the electronics industry, it has not been widely used in the field of biology

Method used

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  • Apparatus and method for investigating molecule
  • Apparatus and method for investigating molecule
  • Apparatus and method for investigating molecule

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0129] Example 1 - Organic pores in plasmonic nanocavities (such as Figure 5 with 6 shown in)

[0130] 1) Arrays of plasmonic structures such as photonic nanocavities 30 are constructed of suitable materials 32 as described in [4], said nanocavities having an inner diameter of 8-10 nm, such as Figure 5 shown in, or have an inner diameter of 4-5nm, as in Image 6 shown in .

[0131] 2) Organic pores 34 such as α-hemolysin are then positioned within these plasmonic structures by means suggested in [13] such that the organic pores 34 are spaced about 1 μm apart.

[0132] 3) The plasmon resonance wavelengths of these nanocavities 30 are then precisely determined and the laser and fluorescent dye spectra are chosen to coincide with the defined plasmon resonances. The fluorochrome spectrum should be slightly red-shifted (20-150 meV) from the plasmon resonance peak.

[0133] 4) Electrolytic transport via the organic pores 34 is performed as described in [10].

[0134] 5) Phot...

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Abstract

Provided is an apparatus for investigating a molecule comprising a channel disposed in a substrate, a metallic moiety capable of plasmon resonance which is associated with the channel in a position suitable for the electromagnetic field produced by the metallic moiety to interact with a molecule passing therethrough, means to induce a molecule to pass through the channel, means to induce surface plasmon resonance in the metallic moiety; and means to detect interaction between the electromagnetic field produced by the metallic moiety and a molecule passing through the channel. Methods of investigating molecules are also provided.

Description

[0001] This application is a divisional application of Chinese patent application 200880114481.1. technical field [0002] The present invention relates to devices and methods for studying molecules, especially biological molecules such as nucleic acids or proteins. The present devices and methods relate to the application of nanoscale technology to the rapid and detailed analysis of these molecular problems. In one aspect, the invention relates to devices and methods for sequencing nucleic acids. Background technique [0003] The ability to rapidly test nucleic acids remains of paramount importance in biology. Although the complete sequences of many genomes, including humans, are now known, and many more will be available, the need to obtain sequence data remains for a number of reasons. Current sequencing technologies are mainly based on Sanger ("dideoxy") technology and are laborious and time consuming. Methods involving detection of the introduction of single nucleoti...

Claims

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Application Information

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IPC IPC(8): C12M1/34
CPCG01N21/658B01L3/5027G01N21/65G01N21/648Y10S977/704Y10S977/733Y10S977/781G01N27/44721G01N27/44756
Inventor 卡梅伦·弗雷林
Owner BASE4 INNOVATION LTD
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