A rapid selection method of the best light source feasibility region in bioluminescence tomography

Abstract

The invention discloses a rapid selecting method of an optimum light source feasibility region of biological self-luminous tomography imaging. The method comprises that a central point and the size of the optimum light source feasibility region are determined; the characteristics that a rebuilt light source tends to a real light source are utilized to determine a point approximating the real light source to be used as the central point of the optimum light source feasibility region after certain times of iteration; and according to the characteristics that a forward equation can analog transmission of photons inside biological tissue, under the condition that the central point of the optimum light source feasibility region is determined, light sources with different sizes are used as analog light sources, forward equations are calculated, and are compared with a surface light intensity value which is really measured in a correlation mode, and finally the optimum light source feasibility region comprising the real light source is obtained. The method effectively reduces the problems that biological self-luminous tomography imaging is lack of determinacy and ill-conditioning, and improves imaging quality.

Description

technical field [0001] The invention relates to molecular image imaging modality-autofluorescence tomography (BLT) technology, in particular to an automatic selection method of the best light source feasibility area. Background technique [0002] Bioluminescence tomography (Bioluminescence Tomography, BLT) is an important branch of molecular imaging, which can analyze and detect many biological processes such as the growth and metastasis of tumors in organisms, the expression of specific genes, etc. at the cellular and molecular levels, with sensitivity High, non-invasive, simple operation, low cost and other advantages, can be widely used in tumor detection, gene therapy and drug development and other fields. [0003] The purpose of BLT reconstruction is to calculate the correct distribution of the light source in the organism by detecting the photon density on the surface of the organism. However, due to the absorption and scattering of the tissues and organs during the pr...

AI Technical Summary

Problems solved by technology

However, due to the lack of intuitive understanding of the bioluminescence source, the selection of the feasibility region of the light source has great randomness and uncertainty, and there is too much human interference in the traditional method of selecting the feasibility region of the light source, it is difficult to achieve automatic and optimal selection

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