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Preparation method of American ginseng extract, and application thereof in preparation of drug for preventing and treating acquired immunodeficiency syndrome

A technology of American ginseng extract and American ginseng is applied in the field of medicine to achieve the effect of reducing the waste of medicinal materials

Inactive Publication Date: 2013-05-22
INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can effectively solve the technical problem of extracting active substances for preventing and treating AIDS from American ginseng

Method used

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  • Preparation method of American ginseng extract, and application thereof in preparation of drug for preventing and treating acquired immunodeficiency syndrome
  • Preparation method of American ginseng extract, and application thereof in preparation of drug for preventing and treating acquired immunodeficiency syndrome
  • Preparation method of American ginseng extract, and application thereof in preparation of drug for preventing and treating acquired immunodeficiency syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] American ginseng was mixed with acetone 6 times its weight and volume, and extracted 3 times with the tissue crushing extraction method. Each extraction was crushed for 30 seconds, with an interval of 2 seconds, and then crushed for 60 seconds, with an interval of 2 seconds, and then crushed for 30 seconds. Filtrate to obtain the filtrate, combine the filtrates for 3 times, concentrate to dryness under reduced pressure, obtain the residue, dissolve the residue in water with a water weight to volume ratio of 1:1 with Panax ginseng, and through column chromatography equipped with DiaionHP-20 macroporous adsorption resin, First elute with 6 times the column volume of deionized water, then elute with 8 times the column volume of 95% ethanol, collect the ethanol eluate, recover the solvent under reduced pressure to dryness, and obtain the American ginseng extract.

Embodiment 2

[0020] Add 15 times the weight volume of American ginseng into acetone, and use the tissue crushing extraction method to extract 3 times, each extraction is crushed for 30 seconds, with an interval of 2 seconds, and then crushed for 60 seconds, with an interval of 2 seconds, and then crushed for 30 seconds. Liquid filtration, get filtrate, merge the filtrate of 3 times, concentrate under reduced pressure to dryness, get residue, be 1:1 water dissolving residue with American ginseng water weight volume ratio, through the column chromatography that DiaionHP-20 macroporous adsorption resin is housed , first eluted with deionized water of 6 times the column volume, then eluted with 95% ethanol at a mass concentration of 8 times the column volume, collected the ethanol eluate, recovered the solvent under reduced pressure to dryness, and obtained the American ginseng extract .

Embodiment 3

[0022] Add 30 times the weight volume of American ginseng into acetone, and use the tissue crushing extraction method to extract 3 times. Each extraction is crushed for 30 seconds, with an interval of 2 seconds, and then crushed for 60 seconds, with an interval of 2 seconds, and then crushed for 30 seconds. Filtrate to obtain the filtrate, combine the filtrates for 3 times, concentrate to dryness under reduced pressure, obtain the residue, dissolve the residue in water with a water weight to volume ratio of 1:1 with Panax ginseng, and through column chromatography equipped with DiaionHP-20 macroporous adsorption resin, First elute with 6 times the column volume of deionized water, then elute with 8 times the column volume of 95% ethanol, collect the ethanol eluate, recover the solvent under reduced pressure to dryness, and obtain the American ginseng extract.

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PUM

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Abstract

The invention relates to a preparation method of a drug for preventing and treating acquired immunodeficiency syndrome and an application thereof, and particularly relates to a preparation method of American ginseng extract, and an application thereof in preparation of the drug for preventing and treating the acquired immunodeficiency syndrome. The American ginseng extract is prepared into oral preparation or injection by adding a pharmaceutical acceptable carrier; and the dosage form of the oral preparation preferably is a capsule, a troche, a pill, a micro pill, oral liquid or granula. The pharmacodynamic test shows that the American ginseng extract can effectively prevent human immunodeficiency virus (HIV) infection under the premise of not damaging the immunologic function, and is free of side effect, so as to achieve prevention and treatment of the acquired immunodeficiency syndrome.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a preparation method and pharmaceutical use of an extract of American ginseng, and more specifically to the application of an extract of American ginseng in the preparation of drugs for preventing and treating AIDS. Background technique [0002] AIDS is acquired immunodeficiency syndrome (Acquired Immunodeficiency Syndrome, AIDS), which is caused by human immunodeficiency virus (Human Immunodeficiency Virus, HIV) infection. Causes partial or complete loss of immune function in the infected person, CD4 + The number of T lymphocytes decreases, the function decreases, and then multi-system, multi-organ, and multi-pathogen co-infection (opportunistic infection) and tumors occur. Since the first AIDS patient appeared in the world in 1981 (my country since 1985), HIV has spread at an astonishing speed around the world. 2.3% of the 34 million infected people. Among them, about 48,000 people we...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61P31/18
Inventor 刘延泽郭会军李青雅肖培根李精云马里奥·堪奇
Owner INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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