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Effective antibacterial traditional Chinese medicine composition

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition including Sophora flavescens extract, composition with antibacterial function, green tea extract and perilla leaf extract, which can solve the problem of drug resistance and other problems

Active Publication Date: 2017-05-03
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The antibacterial effect of some chemical drugs is obvious to all, but a large number of antibiotic applications, whether applied to clinical or other industries such as poultry farming, aquaculture, are all May cause a series of social problems such as drug resistance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0037] Preparation Example 1: Preparation of Sophora flavescens extract

[0038] Sophora flavescens was ground into powder (20-40 mesh), sieved, soaked in 60% ethanol for 2 hours, heated and refluxed for 1.5 hours, extracted twice, combined with extracts; Add 0.5% hydrochloric acid to dilute until the pH value of the solution is 1.5, filter out the insoluble matter, extract the filtrate three times with chloroform, adjust the pH value of the aqueous phase to 10 with ammonia water, extract three times with chloroform, combine the organic layers, evaporate The solvent is removed and dried to obtain Sophora flavescens extract. If not stated otherwise, this extract was used in the following experiments.

preparation example 2

[0039] Preparation Example 2: Preparation of Green Tea Extract

[0040] Soak the green tea with 8 times the amount of water for 12 hours, then heat and extract twice at 80°C for 1.5 hours each time, combine the extracts, filter, concentrate, and dry to obtain the green tea extract. ) 34.44%. If not stated otherwise, this extract was used in the following experiments.

preparation example 3

[0041] Preparation Example 3: Preparation of perilla leaf extract

[0042] Soak perilla leaves with 8 times the amount of water for 12 hours, then heat and extract at 80°C for 2 times, each time for 1.5 hours, combine the extracts, filter, concentrate, and dry to obtain the perilla leaf extract. The yield is ( Calculated by feeding medicinal materials) 21.96%. If not stated otherwise, this extract was used in the following experiments.

[0043] 2. Biological test case part

[0044] In this test example, the antibacterial activity of the traditional Chinese medicine extract or composition was determined by comprehensively using the agar dilution method and the broth dilution method to detect the antibacterial activity. The reagent is the extract obtained in the preparation example (single extract or their mixture in a certain proportion). In the present invention, when the extracts are used in combination to determine the MIC, it is the MIC value obtained by mixing the c...

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Abstract

The invention relates to an effective antibacterial traditional Chinese medicine composition and in particular relates to a traditional Chinese medicine composition. The effective antibacterial traditional Chinese medicine composition includes radix sophorae flavescentis extract, green tea extract and perilla leaf extract as well as random pharmaceutically acceptable auxiliary materials. The invention further relates to a method for preparing the traditional Chinese medicine composition and application of the traditional Chinese medicine composition. Besides, the traditional Chinese medicine composition can be used for preventing microorganism (for example escherichia coli) infection.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine and relates to a composition with antibacterial function, in particular to a traditional Chinese medicine composition comprising Sophora flavescens extract, green tea extract and perilla leaf extract. Background technique [0002] While microorganisms have made great contributions to human progress, they are always threatening human health. For example, the well-known Escherichia coli (E. coli), commonly known as Escherichia coli, was discovered by Escherich in 1885, and has been regarded as a component of normal intestinal flora for a long period of time. are non-pathogenic bacteria. It was not until the middle of the 20th century that some special serotypes of Escherichia coli were recognized to be pathogenic to humans and animals, especially to infants and young animals (poultry), often causing severe diarrhea and sepsis. It is a common prokaryotic organism, according to ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/82A61K36/489A61K36/535A61P31/04
CPCY02A50/30
Inventor 王涛宋新波郝佳刘二伟胡利民韩立峰张祎何俊高秀梅
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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