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Dry suspension of mannose ester, and its preparation method

A kind of technology of dry suspension, glycoside ester

Active Publication Date: 2014-05-28
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the shortcomings of poor water solubility and low bioavailability of the existing sugar glycosides, the present invention invented a dry suspension of sugar glycosides

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 Preparation of glycoside sugar ester dry suspension

[0031] Glycoside sugar ester 50g

[0032] Glycoside 700g

[0033] Aspartame 50g

[0034] Hydroxypropyl cellulose: povidone (weight ratio 3:1) 50g

[0035] Disodium hydrogen phosphate anhydrous 10g

[0036] The preparation method is as follows:

[0037] (1) Precisely weigh the prescription amount of glycosides and pass through an 80-mesh sieve;

[0038] (2) Precisely weigh the prescribed amounts of glycosides, aspartame, hydroxypropyl cellulose, povidone methyl cellulose, and anhydrous disodium hydrogen phosphate, respectively, after passing through an 80 mesh sieve, and increasing in equal amounts well mixed;

[0039] (3) Steps (1) and (2) are mixed uniformly in equal increments to obtain a mixed powder, which is passed through a 40-mesh sieve;

[0040] (5) After passing the intermediate test, the finished product can be obtained by sub-packaging.

Embodiment 2

[0041] Example 2 Preparation of glycoside sugar ester dry suspension

[0042] Glycoside sugar ester 50g

[0043] Glycoside 700g

[0044] Aspartame 50g

[0045] Hydroxypropyl cellulose: povidone (weight ratio 4:1) 50g

[0046] Disodium hydrogen phosphate anhydrous 10g

[0047] The preparation method is the same as in Example 1.

Embodiment 3

[0048] Example 3 Preparation of glycoside sugar ester dry suspension

[0049] Glycoside sugar ester 50g

[0050] Glycoside 700g

[0051] Aspartame 50g

[0052] Hydroxypropyl cellulose: povidone (weight ratio 2:1) 50g

[0053] Disodium hydrogen phosphate anhydrous 10g

[0054] The preparation method is the same as in Example 1.

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PUM

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Abstract

The invention discloses a dry suspension of mannose ester, and its preparation method. The dry suspension of mannose ester comprises 40-100 parts of mannose ester, 600-2200 parts of a filler, 50-200 parts of a flavoring, 40-100 parts of a suspension aid, and 10-40 parts of a flocculating agent. The dry suspension of mannose ester has the advantages of uniform particle distribution, good stability, large distribution area in the stomach and intestine, fast absorption, high bioavailability, and fast medicine effectiveness, and has better medicine effects than a premix of mannose ester.

Description

Technical field [0001] The invention relates to a dry suspension, in particular to a glycoside sugar ester dry suspension and a preparation method thereof, belonging to the field of glycoside sugar ester preparations. Background technique [0002] Dry suspension refers to a liquid preparation in which poorly soluble drugs and suitable auxiliary materials are made into powder or granules, and can be dispersed into a suspension for oral administration by adding water and shaking before use. Dry suspensions are suspensions. After being dispersed with water, they should meet the quality requirements of the suspension. The particles in the suspension should be evenly dispersed. They should not be called down quickly. They should not form cakes after sedimentation. After shaking, After that, it should be dispersed again quickly. In addition to the effectiveness and chemical stability of the ideal suspension (mainly depending on the nature of the main drug), the ideal suspension should...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K31/715A61K47/38A61K47/32A61P3/06
Inventor 王明刚任莉陈阳生
Owner CP PHARMA QINGDAO CO LTD
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