Medicine for treating animal bacterial diseases and preparation method thereof
A bacterial and pharmaceutical technology, which is applied to the field of medicines for treating bacterial diseases of livestock and poultry and their preparation, can solve the problems of difficult control of dosage, short residence time, low bioavailability, etc. Quick and slow release effect
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Embodiment 1
[0034] A medicine for treating bacterial diseases of livestock and poultry, its ingredients include: nisin 0.5g, poloxamer 407 with a mass fraction of 15% and poloxamer 188 with a mass fraction of 5%, a total of 0.3g, poloxamer The mass ratio of 407 and poloxamer 188 is 1:2, triethanolamine 0.3g, glycerol 1.5g, Tween-80 1.0g, di-tert-butylhydroxytoluene 0.01g, ethylparaben 0.01g, add distilled water Dilute to 100ml.
[0035] Dissolve ethylparaben and di-tert-butylhydroxytoluene in distilled water, add Poloxamer 407 and Poloxamer 188 under stirring, stir at 20-30°C for 15-30min to make it swell evenly, and obtain Poloxamer swelling product; in addition, dissolve nisin in water, add glycerin and Tween-80 and stir evenly to obtain nisin solution, add nisin solution to poloxamer swelling product, then add triethanolamine, stir well, use Distilled water was adjusted to 100ml, and finally the drug solution was obtained by filtering with a microporous membrane below 0.45 μm.
[003...
Embodiment 2
[0040] A medicine for treating bacterial diseases of livestock and poultry, the ingredients of which include: 1.0 g of nisin, 0.6 g of poloxamer 407 and poloxamer 188 with a mass ratio of 1:1 and 0.6 g of poloxamer 188, and 0.7 g of triethanolamine g, glycerin 2.6g, Tween-80 2.0g, di-tert-butylhydroxytoluene 0.02g, ethylparaben 0.03g, add distilled water to make up to 100ml.
[0041] Dissolve ethylparaben and di-tert-butylhydroxytoluene in distilled water, add Poloxamer 407 and Poloxamer 188 under stirring, stir at 20-30°C for 15-30min to make it swell evenly, and obtain Poloxamer swelling product; in addition, dissolve nisin in water, add glycerin and Tween-80 and stir evenly to obtain nisin solution, add nisin solution to poloxamer swelling product, then add triethanolamine, stir well, use Distilled water was adjusted to 100ml, and finally the drug solution was obtained by filtering with a microporous membrane below 0.45 μm.
[0042] Drug solutions are prepared as injection...
Embodiment 3
[0046] A medicine for treating bacterial diseases of livestock and poultry, the ingredients of which include: nisin 2.0g, poloxamer 407 with a mass fraction of 20% and poloxamer 188 with a mass fraction of 10%, a total of 1.0g, poloxamer The mass ratio of 407 and poloxamer 188 is 1:4, 1.2g triethanolamine, 3.5g glycerin, 3.0g Tween-80, 0.03g di-tert-butylhydroxytoluene, 0.02g ethylparaben, add distilled water Dilute to 100ml.
[0047] Dissolve ethylparaben and di-tert-butylhydroxytoluene in distilled water, add Poloxamer 407 and Poloxamer 188 under stirring, stir at 20-30°C for 15-30min to make it swell evenly, and obtain Poloxamer swelling product; in addition, dissolve nisin in water, add glycerin and Tween-80 and stir evenly to obtain nisin solution, add nisin solution to poloxamer swelling product, then add triethanolamine, stir well, use Distilled water was adjusted to 100ml, and finally the drug solution was obtained by filtering with a microporous membrane below 0.45 μ...
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