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Application of alpha-lipoic acid, acetyl-L-carnitine, coenzyme Q10 and hydroxytyrosol composition for preventing and treating amyotrophy

A technology of acetyl-L-carnitine and hydroxytyrosol, which is applied in the fields of biology and medicine, can solve the problems of incapable of inhibiting muscle atrophy and improving muscle function, and achieves improvement of motor function decline, clear intervention target, and no toxic and side effects. Effect

Active Publication Date: 2013-06-26
西安小天使健康科技研究院有限公司
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Problems solved by technology

When coenzyme Q10 and other antioxidants are supplemented, the effect of inhibiting muscle atrophy and improving muscle function cannot be achieved

Method used

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  • Application of alpha-lipoic acid, acetyl-L-carnitine, coenzyme Q10 and hydroxytyrosol composition for preventing and treating amyotrophy
  • Application of alpha-lipoic acid, acetyl-L-carnitine, coenzyme Q10 and hydroxytyrosol composition for preventing and treating amyotrophy
  • Application of alpha-lipoic acid, acetyl-L-carnitine, coenzyme Q10 and hydroxytyrosol composition for preventing and treating amyotrophy

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Experimental program
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Embodiment Construction

[0026] 1. Animal feeding

[0027] Sprague Dawley male rats were purchased from Shanghai Slack Animal Co., Ltd. The rats were kept in a room with controllable temperature (22°C to 28°C) and humidity (60%). The lights in the room were maintained in a 12-hour day and 12-hour night cycle. During the experiment, the rats were free to eat and drink. Ingress of water.

[0028] 2. Establishment of the hindlimb unloading model

[0029] The experimental rats were divided into six groups, 10 in each group. The six groups were: (1) normal control group; (2) hindlimb unloading group for 3 weeks; (3) hindlimb unloading group for 3 weeks plus rehabilitation for 1 week; (4) normal control group with daily supplementation of nutrients. (5) The hind limbs lost load for 3 weeks while adding nutrients every day. (4) The hindlimb was unloaded for 3 weeks and recovered for 1 week while adding nutrients every day. The experimental period is 4 weeks. Nutrient compatibility: daily alpha-lipoic aci...

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Abstract

The invention relates to an application of an alpha-lipoic acid, acetyl-L-carnitine, coenzyme Q10 and hydroxytyrosol composition for preventing and treating amyotrophy, wherein the alpha-lipoic acid, the acetyl-L-carnitine, the coenzyme Q10 and the hydroxytyrosol are composited in appropriate proportion, so that the generation of mitochondria in muscle can be promoted; the loss of the mitochondria can be inhibited; and the muscle function can be improved. Therefore, the atrophy of muscle fibers during the generation process of the amyotrophy is inhibited effectively; and the growth of the muscle fibers during the recuperation process of the amyotrophy is promoted. In addition, the motion function decline caused by the amyotrophy is lightened effectively; and the improvement in the motion function during the recuperation process of the amyotrophy is promoted.

Description

technical field [0001] The invention relates to the fields of biology and medicine, in particular to alpha-lipoic acid, acetyl-L-carnitine, coenzyme Q 10 The application of compatibility with hydroxytyrosol in the prevention and treatment of muscular atrophy. Background technique [0002] Skeletal muscle atrophy refers to pathological changes such as mass loss or loss of function of skeletal muscle, mainly including disuse muscle atrophy caused by reduced muscle use and neurogenic muscle atrophy caused by damage to nerves involved in muscle control. Muscle atrophy is mainly manifested as decreased muscle protein content, smaller muscle fiber diameter, and decreased muscle strength and fatigue resistance. [0003] In addition to removing the primary cause of muscle atrophy, the prevention and treatment of muscle atrophy is currently mainly through appropriate exercise training, giving muscle loads, and delaying the occurrence of muscle atrophy. However, based on individual ...

Claims

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Application Information

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IPC IPC(8): A61K31/385A61K31/221A61K31/122A61K31/05A61P21/00
Inventor 刘健康龙建纲刘静彭韵桦
Owner 西安小天使健康科技研究院有限公司
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