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Anti-AIDS (Acquired Immune Deficiency Syndrome) compound preparation and preparation method thereof

A compound preparation and anti-AIDS technology, which is applied in the field of medicine and can solve problems such as complex processes

Inactive Publication Date: 2013-06-26
SHANGHAI DESANO BIO PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The process is more complex

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0099] The preparation method of concrete anti-AIDS compound preparation of the present invention comprises steps:

[0100] a) Zidovudine, lamivudine, nevirapine and internal excipients are pretreated (such as pulverized or sieved), wherein the internal excipients include disintegrants and optional fillers;

[0101] b) After mixing the pretreated zidovudine, lamivudine, nevirapine and internally added excipients (such as mixing in a wet granulator or mixer), the mixed material is obtained, and the mixed material is subjected to wet granulation (such as high-shear stirring granulation or one-step fluidized bed granulation) to obtain granulated materials;

[0102] c) After mixing the granulated material obtained in step b and the additional auxiliary materials, performing tablet compression or capsule filling treatment, thereby obtaining anti-AIDS compound tablets or capsules,

[0103] Wherein, the added auxiliary materials include lubricants, optional disintegrants and optiona...

Embodiment 1

[0129] Example 1 Tablet 1

[0130] Pass zidovudine, lamivudine, nevirapine, microcrystalline cellulose (filler), and sodium starch glycolate (disintegrant) through a 60-mesh sieve for pretreatment, and accurately weigh them according to the prescription amount (see Table 1). Mix evenly, wet granulate with 2wt% HPMC aqueous solution as binder, dry at 60°C, granulate, add sodium carboxymethyl starch (disintegrant), magnesium stearate (lubricant) and mix, and perform intermediate detection after uniformity , tableting, and film coating with a commercially available conventional high-efficiency coating machine BGB-150D (Zhejiang Xiaolun).

[0131] Table 1

[0132] Element

Embodiment 2

[0133] Example 2 Tablet 2

[0134] Pass zidovudine, lamivudine, nevirapine, microcrystalline cellulose (filler), carboxymethyl starch sodium (disintegrant) through a 40-mesh sieve for pretreatment, and accurately weigh according to the prescription amount (see Table 2). Mix evenly, wet granulate with 10wt% PVP aqueous solution as binder, dry at 50°C, granulate, add magnesium stearate (lubricant) and mix evenly, carry out intermediate detection, tabletting, use commercially available conventional high-efficiency packaging Coating machine BGB-150D (Zhejiang Xiaolun) for film coating.

[0135] Table 2

[0136] Element

[0137] Nevirapine

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PUM

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Abstract

The invention discloses an anti-AIDS (Acquired Immune Deficiency Syndrome) compound preparation and a preparation method thereof. In particular, the compound preparation comprises 1) safe zidovudine in effective amount for treatment or pharmaceutically acceptable derivatives; 2) safe lamivudine in effective amount for treatment or pharmaceutically acceptable derivatives; 3) safe nevirapine in effective amount for treatment or pharmaceutically acceptable derivatives; 4) a disintegrating agent; and 5) pharmaceutically acceptable carriers or auxiliary materials beside the disintegrating agent, wherein the content of the disintegrating agent is 4-15wt% of total weight the compound preparation. The compound preparation is quick to disintegrate and adequate to dissolve. The invention further discloses a method for preparing the compound preparation.

Description

technical field [0001] The invention belongs to the field of medicine, in particular, relates to an anti-AIDS compound preparation and a preparation method thereof, more specifically, relates to a compound preparation comprising zidovudine, lamivudine and nevirapine and a preparation method thereof. Background technique [0002] AIDS is rampant in the world, seriously threatening human health and survival, and has had a devastating impact on individuals, communities and countries. Since the first case of AIDS was discovered in my country in 1985, the number of HIV infections has been increasing. Especially high prevalence occurs in local areas and specific populations. The number of reported HIV-infected people across the country has risen sharply, the number of epidemics has increased significantly, the number of deaths has continued to increase, and the proportion of women infected has increased. By the end of October 2010, more than 370,000 HIV-infected persons and pati...

Claims

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Application Information

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IPC IPC(8): A61K31/7072A61K31/551A61K31/513A61P31/18
Inventor 李金亮陈亚姿陈建秋吴灵静马玲沈婧
Owner SHANGHAI DESANO BIO PHARM CO LTD
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