Use of 4,7-dihydrotetrazyl[1,5-alpha]pyrimidine compound and its derivatives in preparation of drug for prevention or treatment on cerebral hemorrhage
A technology of dihydrotetrazole and compound, applied in the field of compound, can solve problems such as limited
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[0042] The present invention will be further described below in conjunction with experiments and experimental data.
[0043] The 4,7-dihydrotetrazol[1,5-α]pyrimidine compounds and their derivatives used in the following examples were all purchased from Chembridge Company (San Diego, USA).
[0044] In the following ROCK1 enzyme inhibitory activity experiments, zebrafish cerebral hemorrhage drug efficacy evaluation experiments, and mouse acute toxicity experiments, the compound with curative effect used is 7-(4-hydroxy-3-methoxyphenyl)-5- Methyl-6-carboxylate benzyl-4,7-dihydrotetrazole (1,5-α) pyrimidine, its structural formula is:
[0045]
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