Compound with base skeleton of 1,6-methylene-[10]-annulene and use thereof
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
- Publication Date
- 2003-10-22
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] This patent relates to a compound with a basic skeleton of 1,6-methylene-
[10] -annulene and its application. These compounds were efficiently synthesized using fluorosulfonyl fluoride-induced carbocation rearrangement reactions. This class of compounds has been shown to have anticancer activity and is an antitumor compound. Background technique
[0002] In order to discover and develop new drugs, the search for natural or non-natural compounds with special biological activity and unique chemical structure has always been the goal pursued by chemists, biologists and drug manufacturers. To this end, natural product chemists are tirelessly and constantly changing methods to find novel natural compounds with special biological activities and unique chemical structures from the biological world; medicinal chemists and synthetic chemists tirelessly design and synthesize compounds based on the knowledge that humans have acquired. new molecules. Obviously, d...