Force spectrometer for measuring intermolecular forces

A technology of intermolecular force and force spectrum, which is applied in the measurement of the elastic deformation force of measuring gauges, instruments, scanning probe technology, etc., can solve the problems of high difficulty in manual needle operation and thermal interference of atomic force microscope, and achieve The effect of reducing the difficulty of operation

Active Publication Date: 2015-07-15
苏州银炙新材料科技有限公司
View PDF10 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The problem to be solved by the present invention is: the problem that the atomic force microscope is disturbed by heat and the manual operation is difficult

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Force spectrometer for measuring intermolecular forces

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0013] The present invention will be described in further detail below in conjunction with the accompanying drawings.

[0014] Such as figure 1 As shown, a force spectrometer for measuring intermolecular forces includes a data analysis device 1, an acquisition control circuit 2, a positioning platform 3, an elastic cantilever 4, a laser generator 51, a first mirror 52, and a second mirror 53 , a laser detector 54 , an LED lamp 61 , and a CCD imaging device 62 . The elastic cantilever 4 is a fixed end at one end and a dynamic end at the other end. A needle point 41 is installed under the dynamic end of the elastic cantilever 4, the needle point 41 is made of silicon nitride material, and a mirror surface is above the dynamic end for reflecting laser light. The fixed end of the elastic cantilever 4 is fixed on the electric motor 42 . The electric motor 42 is fixed on the frame 7 . The positioning table 3 is a piezoelectric ceramic positioner, that is, a positioner manufactur...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a force spectrometer for measuring intermolecular forces. The force spectrometer comprises a force measurement unit, an acquisition control circuit and a data analysis device. The force measurement unit comprises an elastic cantilever, a location stage, a cantilever deformation amplification device, an electric motor, an LED (light emitting diode) lamp and a CCD (charge coupled device) imaging device, wherein the elastic cantilever is provided with one fixed end and one moving end; a needle tip is arranged on the lower surface of the moving end of the elastic cantilever; the fixed end of the elastic cantilever is connected with the electric motor; the location stage is a piezoelectric ceramic locator; and the cantilever deformation amplification device comprises a laser generator, a first mirror, a second mirror and a laser detector. The acquisition control circuit is connected with the location stage, the laser generator, the laser detector and the data analysis device and comprises a proportional integral differential control circuit. The force spectrometer provided by the invention eliminates thermal disturbance to the cantilever, can greatly lower the operation difficulty by changing manual needle laying operation to automatic operation, and can automatically make feedback compensation after the cantilever generates thermal drift.

Description

technical field [0001] The invention relates to instrument control and detection. Background technique [0002] The interaction between biomolecules plays an important role in organisms, such as signal transduction, material transport and environmental response. Therefore, measuring the interaction between biomolecules is an important and necessary means in biochemical research and medical detection. The current mainstream measurement methods are isothermal titration calorimetry and surface plasmon resonance. In recent years, the development of single molecule force spectroscopy has made it possible to measure the interaction between biomolecules at the single molecule level. Single-molecule force spectroscopy needs to be able to quantitatively characterize the interaction between individual biomolecules, and must achieve extremely high mechanical resolution and distance resolution. At present, the main methods used are testing methods based on atomic force microscope (AF...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): G01L1/04G01Q80/00
Inventor 曹毅秦猛邹大维
Owner 苏州银炙新材料科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap