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Self-assembled nanospheres, hydrogels and their preparation methods based on commercial amino acids

An amino acid and nanosphere technology, which is applied in the preparation of microspheres, nanotechnology for materials and surface science, nanotechnology, etc., to achieve the effects of controllable size, good stability and uniform morphology distribution

Active Publication Date: 2015-10-21
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] So far, in terms of nanospheres, there is no report on the self-assembly of Fmoc amino acids into nanospheres; in terms of supramolecular hydrogels, there is no report on the gelation of Fmoc amino acids by simple ultrasound

Method used

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  • Self-assembled nanospheres, hydrogels and their preparation methods based on commercial amino acids
  • Self-assembled nanospheres, hydrogels and their preparation methods based on commercial amino acids
  • Self-assembled nanospheres, hydrogels and their preparation methods based on commercial amino acids

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1 (preparation of self-assembled nanospheres):

[0040] Weigh Fmoc-His(Trt)-OH or Fmoc-Cys(Trt)-OH or Fmoc-Asn(Trt)-OH or Fmoc-Gln(Trt)-OH or Fmoc-His(Fmoc)-OH 1mg (0.1mg~ 2mg is acceptable, but 1mg is the best) in a 5mL serum bottle, add 10μL dimethyl sulfoxide (DMSO) to prepare a stock solution with a concentration of 100mg / mL (80mg / mL~120mg / mL is acceptable, but 100mg / mL mL is the best), sonicate for 10-20 seconds until the Fmoc amino acid is dissolved, and pipette 990 μL of phosphate buffer solution (PBS7.4) with a pH of 7.4. Ultrasound for 2-3 seconds promotes the self-assembly of Fmoc amino acids, and the nanospheres are prepared.

Embodiment 2

[0041] Example 2 (preparation of self-assembled Fmoc-Met-OH hydrogel):

[0042] Weigh 3mg Fmoc-Met-OH into a 5mL serum bottle (2-5mg is acceptable, 3mg is the best), add 30μL DMSO to prepare a stock solution with a concentration of 100mg / mL (80mg / mL-120mg / mL is acceptable) , but 100mg / mL is the best), sonicate for 10-20 seconds to dissolve Fmoc-Met-OH, then pipette 970μL PBS7.4 with a pipette gun. Ultrasound for 10-30 minutes promotes the self-assembly of Fmoc amino acids, and the Fmoc-Met-OH hydrogel is prepared.

Embodiment 3

[0043] Example 3 (preparation of self-assembled Fmoc-Trp-OH hydrogel):

[0044] Weigh 4mg of Fmoc-Trp-OH into a 5mL serum bottle (3-6mg is acceptable, 4mg is the best), add 40μL DMSO to prepare a stock solution with a concentration of 100mg / mL (80mg / mL-120mg / mL is acceptable) , but 100mg / mL is the best), sonicate for 10-20 seconds to dissolve Fmoc-Trp-OH, then pipette 960μL PBS7.4 with a pipette gun. Ultrasound for 10-30 minutes promotes the self-assembly of Fmoc amino acids, and the Fmoc-Trp-OH hydrogel is prepared.

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Abstract

The invention discloses a self-assembly nanosphere or hydrogel based on commercial amino acid and a preparation method thereof. The method provided by the invention comprises the following operating steps: taking a certain amount of commercial amino acid, dissolving by the use of dimethyl sulfoxide to obtain a stock solution, diluting by the use of a phosphoric acid buffer at a pH of 7.4, and performing ultrasound so as to obtain the nanosphere or hydrogel. The nanosphere prepared in the invention is simple and cheap, morphology and distribution of the nanosphere are uniform, and the size of the nanosphere is easy to regulate and control according to concentration. According to the prepared hydrogel, gelation can be realized only by ultrasound; and the hydrogel is not easy to deteriorate. The nanosphere and hydrogel obtained in the invention are based on the commercial amino acid which are cheap and can be obtained in quantity. In addition, the preparation method is simple and fast. The prepared material has good stability, and the preparation method paves the way for industrial application of the nanosphere and hydrogel.

Description

technical field [0001] The invention relates to a class of self-assembled nanospheres, hydrogels and preparation methods based on commercial amino acids. Specifically, it is a class of commercialized N-fluorenylmethoxycarbonyl-amino acids (Fmoc-amino acids), through intermolecular hydrogen bonding and aromatic stacking, so that self-assembled nanospheres and supramolecular hydrogels can be prepared in large quantities with high efficiency. methods and products. Background technique [0002] Self-assembly is a branch of supramolecular chemistry, which is the process of spontaneously organizing into ordered or specific structures without human intervention by using the non-chemical bond forces between molecules. (Science, 2002, 295, 2418-2421) Self-assembly is a common phenomenon in nature and technological life. It was not until the 1987 Nobel Prize in Chemistry was awarded to three scientists (Jean-Marie Lehn, Donald J. Cram, and Charles J. Pedersen) who studied supramolec...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/02B82Y30/00B82Y40/00
Inventor 张翼戴璇孙志方石婷婷赵欣欣
Owner CENT SOUTH UNIV
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