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Granulated high-molecular film, and preparation method and application thereof

A polymer film and granulation technology, applied in biochemical equipment and methods, coatings, medical science, etc., can solve the problems of high cost, long preparation time, and difficulty in control, and achieve low cost and simple preparation process. Effect

Inactive Publication Date: 2013-08-14
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The prepared microscopic morphology is precise, but the cost is expensive, which is not conducive to large-scale production
[0006] 3) Mold printing and embossing method, attaching a mold with regular surface topography to the surface of the polymer membrane, and printing and embossing the corresponding microscopic topography at a certain temperature, this method is simple to operate, but difficult to control, and often occurs The phenomenon of uneven printing
This large class of methods all have the problem of long preparation time or high cost

Method used

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  • Granulated high-molecular film, and preparation method and application thereof
  • Granulated high-molecular film, and preparation method and application thereof
  • Granulated high-molecular film, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Preparation of micron-sized polylactic acid particles.

[0040] Weigh 2g of polylactic acid and dissolve it in 20ml of dichloromethane, reflux and condense at high temperature for 1 hour until completely dissolved to form an organic phase. Weigh 0.1g of polyvinyl alcohol and dissolve it in 1000ml of water, and dissolve it at high temperature for 1 hour until it is completely dissolved to form a water phase. Take out 5ml of the organic phase and 150ml of the aqueous phase and place them in a dry 250ml beaker, and then perform homogenization treatment at 1000 rpm for 1 minute to form an emulsion. Immediately pour the emulsion into a rotary evaporator to remove dichloromethane.

[0041] Detected by a particle size analyzer, the prepared particles were micron-sized polylactic acid particles of 2.52 μm.

Embodiment 2

[0043] Preparation of micron-sized poly-3-hydroxybutyrate particles.

[0044] Weigh 3g of poly-3-hydroxybutyrate and dissolve it in 20ml of dichloromethane / chloroform (volume ratio 80:20), reflux at high temperature for 1 hour until completely dissolved to form an organic phase. Weigh 30g of polyvinyl alcohol and dissolve it in 1000ml of water, and dissolve it at high temperature for 1 hour until it is completely dissolved to form a water phase. Take out 5ml of the above-mentioned organic phase and 100ml of the aqueous phase and place them in a dry 250ml beaker, and then perform homogenization at 1500 rpm for 3 minutes to form an emulsion. Immediately pour the emulsion into a rotary evaporator to remove dichloromethane. \

[0045] As detected by a particle size analyzer, the particle size of the prepared particles was 2.98 μm.

Embodiment 3

[0047] Preparation of Nanoscale Polylactic Acid Particles.

[0048] Weigh 1g of polylactic acid and dissolve it in 20ml of dichloromethane, reflux and condense at high temperature for 1 hour until completely dissolved to form an organic phase. Weigh 40g of polyvinyl alcohol and dissolve it in 1000ml of water, and dissolve it at high temperature for 1 hour until it is completely dissolved to form a water phase. Take out 5ml of the above-mentioned organic phase and 200ml of the aqueous phase and place them in a dry 250ml beaker, and then perform ultrasonic treatment (power 100W, total working time 30 minutes) to form an emulsion. Immediately pour the emulsion into a rotary evaporator to remove dichloromethane.

[0049] Detected by a particle size analyzer, the particle size of the prepared particles was 880nm.

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Abstract

The invention relates to a granulated high-molecular film. The granulated high-molecular film is composed of high-molecular granules and a high-molecular film, and the high-molecular granules are inlaid in the surface of the smooth high-molecular film, so the granulated high-molecular film a rough surface morphology and is in favor of the adherence and propagation of cells; and the sizes of the surface granules are 50nm-3mum, and a distance between each two of the granules is 100nm-25mum. The invention also relates to a preparation method of the granulated high-molecular film. The method has a simple operation and a low cost, and the prepared granulated high-molecular film is a biodegradable material and allows nanometer granules or micrometer granules having different materials, different sizes and different distances to be inlaid on the surface. The granulated high-molecular film is used for culturing cells in the tissue engineering, has a better biocompatibility than traditional smooth high-molecular films, and is in favor of the adherence and propagation of the cells.

Description

technical field [0001] The invention relates to a granulated polymer membrane and a preparation method thereof, in particular to the application of the granulated polymer membrane as a new membrane matrix for culturing cells in the field of tissue engineering. Background technique [0002] In the field of tissue engineering, biomaterials are the most basic framework for tissue engineering and the essential material basis for tissue engineering research. Studies have shown that ideal biomaterials should have the following characteristics: 1) good biocompatibility; 2) good biomechanical properties; 3) suitable biodegradability; 4) special material microstructure. Among them, the special microstructure of the material plays a pivotal role in the whole tissue process. A reasonable and special material microstructure can be conducive to cell adhesion and proliferation, and a surface that is too smooth or too rough is not conducive to cell adhesion. [0003] A large number of stu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/50C08J7/04C08L67/04C12N5/00
Inventor 魏岱旭钟建闫志强何丹农
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH