Traditional Chinese medicine for treating Alzheimer disease as well as preparation method and application thereof

Abstract

The invention discloses a traditional Chinese medicine for treating Alzheimer disease as well as a preparation method and application thereof. The traditional Chinese medicine comprises the following components in parts by mass: 15 parts of codonopsis pilosula, 15 parts of astragalus mongholicus, 12 parts of rhizoma polygonati, 6 parts of polygonum multiflorum, 10 parts of curcuma aromatica, 8 parts of rhizoma acori graminei, 10 parts of ligusticum wallichii and 8 parts of earthworm. The method comprises the following steps of: adding the curcuma aromatica, the rhizoma acori graminei and the ligusticum wallichii into deionized water, heating for distilling and extracting volatile oil, dehydrating the volatile oil, clathrating with beta-cyclodextrin and drying at low temperature; collecting a distilled water solution with another vessel, adding the codonopsis pilosula, the astragalus mongholicus, the rhizoma polygonati, the polygonum multiflorum and earthworm into water, decorating, mixing decoctions, filtering to obtain filtrate, mixing the filtrate with the distilled water solution, concentrating to obtain concentrate, adding 95% ethanol to the concentrate to ensure that the alcohol precipitation concentration is 60%, fully stirring, standing for 24-48 hours, filtering to obtain filtrate, recovering ethanol from the filtrate, concentrate the filtrate subjected to ethanol removal to form thick paste and performing microwave drying on the thick paste to form a dry extract; and crushing the dry extract, adding a defined amount of dextrin or starch, performing wet granulation, drying and granulation, adding a volatile oil clathrate compound and uniformly mixing. By adopting methods of invigorating spleen and kidney, eliminating phlegm and dispersing blood stasis, the brain premature senility and brain aging are prevented and intervened, thereby delaying the development of the Alzheimer disease, improving the clinical symptoms and improving the life quality of patients.

Description

technical field [0001] The invention relates to a medicine for treating Alzheimer's disease, in particular to a traditional Chinese medicine for treating Alzheimer's disease and its preparation method and application. Background technique [0002] Alzheimer's disease (AD) is a disease characterized by acquired mental decline and behavioral personality changes. In the absence of disturbance of consciousness, memory and cognitive dysfunction are associated with changes in speech, visuospatial skills, affect, or personality that affect social activities. The onset of the patient is insidious, and the early symptoms are short-term memory loss, personality changes, intelligence decline, poor spatial orientation, often lost, lost, or reduced initiative, emotional instability, but daily life can still be maintained. Further development will lead to cognitive decline, aphasia, agnosia, and signs of nervous system positioning, inability to take care of oneself in daily life, often s...

AI Technical Summary

Problems solved by technology

At present, the drugs for the treatment of Alzheimer's disease, such as cholinesterase inhibitors, antioxidants, anti-inflammatory drugs, drugs that inhibit amyloid formation, estrogen, nerve growth factor, etc., are all targeted at a certain pathological characteristic of the disease. Intervention, can not prevent or delay the course of Alzheimer's disease, the effect is not ideal