Traditional Chinese medicine for treating Alzheimer disease as well as preparation method and application thereof
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A technology of Alzheimer's disease and traditional Chinese medicine, which is applied in the field of traditional Chinese medicine for the treatment of Alzheimer's disease and its preparation, can solve the problems that the course of Alzheimer's disease cannot be prevented or delayed, and the effect is not ideal, so as to achieve prevention and intervention Effects of premature aging, improving clinical symptoms, and delaying development
Active Publication Date: 2015-02-18
杨文明
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At present, the drugs for the treatment of Alzheimer's disease, such as cholinesterase inhibitors, antioxidants, anti-inflammatory drugs, drugs that inhibit amyloid formation, estrogen, nerve growth factor, etc., are all targeted at a certain pathological characteristic of the disease. Intervention, can not prevent or delay the course of Alzheimer's disease, the effect is not ideal
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[0032] Using β-amyloid protein intracerebroventricular injection combined with transfer growth factor β1 intracerebral injection to produce both behavioral changes (learning and memory impairment) and typical pathology (β-amyloid deposition plaques) and Based on the experimental rat model of Alzheimer's disease with neurobiochemical characteristics, the pharmacodynamic research on the influence of the above traditional Chinese medicine on the learning and memory of the model rats and the cholinergic neurotransmitters in the cerebral cortex and hippocampus structure area was carried out. After the model was successfully modeled (confirmed by behavioral tests and pathological observations), administration began. Two groups of rats were given the aqueous solution of the present invention for intragastric administration, and the normal group and the model group were given equal volumes of normal saline for intragastric administration; Weinaofukang suspension for 28 consecutive days...
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[0037] The traditional Chinese medicine for treating Alzheimer's disease, wherein the raw materials are composed according to the following weight ratio:
[0040](1) Add 10 to 15 times the amount of deionized water to the turmeric, calamus and chuanxiong in the prescription, heat and distill to extract the volatile oil, dehydrate the extracted volatile oil with anhydrous sodium sulfite, and then clathrate it with β-cyclodextrin , low temperature drying. The distilled aqueous solution is collected in another device; (2) Add water to decoct the five medicinal materials of Codonopsis pilosula, Radix Astragali, Polygonatum, Polygonum multiflorum, and Earthworm in the prescription for 2 to 3 times, combine the decoction, filter, and combine the filtrate wi...
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Abstract
The invention discloses a traditional Chinese medicine for treating Alzheimer disease as well as a preparation method and application thereof. The traditional Chinese medicine comprises the following components in parts by mass: 15 parts of codonopsis pilosula, 15 parts of astragalus mongholicus, 12 parts of rhizoma polygonati, 6 parts of polygonum multiflorum, 10 parts of curcuma aromatica, 8 parts of rhizoma acori graminei, 10 parts of ligusticum wallichii and 8 parts of earthworm. The method comprises the following steps of: adding the curcuma aromatica, the rhizoma acori graminei and the ligusticum wallichii into deionized water, heating for distilling and extracting volatile oil, dehydrating the volatile oil, clathrating with beta-cyclodextrin and drying at low temperature; collecting a distilled water solution with another vessel, adding the codonopsis pilosula, the astragalus mongholicus, the rhizoma polygonati, the polygonum multiflorum and earthworm into water, decorating, mixing decoctions, filtering to obtain filtrate, mixing the filtrate with the distilled water solution, concentrating to obtain concentrate, adding 95% ethanol to the concentrate to ensure that the alcohol precipitation concentration is 60%, fully stirring, standing for 24-48 hours, filtering to obtain filtrate, recovering ethanol from the filtrate, concentrate the filtrate subjected to ethanol removal to form thick paste and performing microwave drying on the thick paste to form a dry extract; and crushing the dry extract, adding a defined amount of dextrin or starch, performing wet granulation, drying and granulation, adding a volatile oil clathrate compound and uniformly mixing. By adopting methods of invigorating spleen and kidney, eliminating phlegm and dispersing blood stasis, the brain premature senility and brain aging are prevented and intervened, thereby delaying the development of the Alzheimer disease, improving the clinical symptoms and improving the life quality of patients.
Description
technical field [0001] The invention relates to a medicine for treating Alzheimer's disease, in particular to a traditional Chinese medicine for treating Alzheimer's disease and its preparation method and application. Background technique [0002] Alzheimer's disease (AD) is a disease characterized by acquired mental decline and behavioral personality changes. In the absence of disturbance of consciousness, memory and cognitive dysfunction are associated with changes in speech, visuospatial skills, affect, or personality that affect social activities. The onset of the patient is insidious, and the early symptoms are short-term memory loss, personality changes, intelligence decline, poor spatial orientation, often lost, lost, or reduced initiative, emotional instability, but daily life can still be maintained. Further development will lead to cognitive decline, aphasia, agnosia, and signs of nervous system positioning, inability to take care of oneself in daily life, often s...
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