Mixed monolithic gel medium and preparation method thereof

A crystal-colloid medium and mixed technology, applied in chemical instruments and methods, other chemical processes, anion exchange, etc., can solve the problems of single and lack of functional groups, achieve good channel connectivity, high porosity, and improve separation performance effect
CN103252218BActive Publication Date: 2015-08-05ZHEJIANG UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG UNIV OF TECH
Publication Date
2015-08-05

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Abstract

Disclosed are a hybrid integrated crystal gel separation medium with super-macropore having hydrophobic benzyl-anion exchange tertiary amino group and preparation method thereof. The aperture of the crystal gel medium is 1-300 μm, the porosity is 85-96 %, the aqueous phase permeability is 2×10-12-6×10-12 m2, the described crystal gel medium has a functional group of hydrophobic benzyl-anion exchange tertiary amino shown in the formula (I). The crystal gel medium polymer chain simultaneously contains an amino-type ion exchange group and a benzyl with certain hydrophobic function, which can help to form multi-point adsorption with biological macromolecules, such as protein, to improve the separation performance. The medium has excellent basic properties of other crystal gel medium, such as high porosity, good pore canal connectivity, certain mechanical strength and reconverting into an original shape quickly when absorbing water again after drying, etc. The medium has broad application prospects in biochemical separation field; n is a positive integer in the formula (I).
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Description

(1) Technical field

[0001] The invention relates to a super-macroporous mixed monolithic gel separation medium and a preparation method thereof, in particular to a hybrid monolithic crystal gel medium with hydrophobic benzyl-anion-exchange tertiary amino groups and a preparation method thereof. (2) Background technology

[0002] The crystal-gel separation medium has ultra-large pores ranging in size from a few microns to hundreds of microns, allowing complex fluids such as complex fermentation broth, culture fluid, or transformation fluid containing microbial cell fragments to pass directly through the bed, and can achieve rapid biomacromolecular substances Separation has important application prospects in the downstream field of biology. It is of great significance to study and develop new ion-exchange gel media with different functional groups.

[0003] At present, there are few reports on mixed crystal-gel separation media at home and abroad, and there are few reports on...

Claims

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