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Traditional Chinese medicine for treating coronary heart disease

A technology of coronary heart disease and traditional Chinese medicine, applied in the field of traditional Chinese medicine for the treatment of coronary heart disease, to achieve the effects of reduced curative effect, slow onset of effect, and improvement of myocardial ischemia

Inactive Publication Date: 2013-08-28
SUZHOU FAMO BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the drugs used clinically are chemical drugs. Due to various reasons, there are various side effects.

Method used

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  • Traditional Chinese medicine for treating coronary heart disease
  • Traditional Chinese medicine for treating coronary heart disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: optimal ratio screening

[0013] 1. Test drug

[0014] 1.1 Total saponins of Panax notoginseng: Kunming Accordson Pharmaceutical Co., Ltd., ginsenoside Rb1 > 30%, ginsenoside Rg1 > 20%, Panax notoginsenoside R1 > 5%, the total amount > 60%.

[0015] Preparation and administration method: Prepare the required concentration with normal saline before use.

[0016] 1.2 Scutellarin: Yunnan Yuxi Wanfang Natural Medicine Co., Ltd., containing scutellarin >95%.

[0017] Preparation and administration method: Prepare the required concentration with normal saline before use.

[0018] 2. Reagents

[0019] Isoproterenol hydrochloride: Shanghai Hefeng Pharmaceutical Co., Ltd.

[0020] 3. Test animals

[0021] Kunming mice: weight 18-22g, half male and half male, provided by Animal Center of Shenyang Pharmaceutical University.

[0022] 4. Experimental methods and results

[0023] 1.1 Using the uniform design method to screen the optimal ratio of Panax notoginseng...

Embodiment 2

[0029] Embodiment 2: Analysis and Evaluation of Optimum Proportioning Effectiveness

[0030] The tested animals were anesthetized with urethane intraperitoneally (1.2g / kg), fixed in the supine position, and connected to the electrocardiogram machine with needle electrodes to record the standard II lead electrocardiogram (ECG). Continuous administration for 7 days by the above dose, 1 hour after administration on the 7th day, subcutaneous injection of isoproterenol (2mg / kg) induces acute myocardial ischemia in rats, observe the 5′, 10', 15', 20', 25', 30' ECG ST segment deviation from the baseline in millivolts. The ∑S-T total offset value of the marked lead II was used as the observation index to measure the degree of myocardial injury, and the significance comparison was carried out. The results are shown in Table 4. Each dose group can significantly reduce the ST-segment deviation caused by myocardial ischemia caused by subcutaneous injection of isoproterenol, and there is ...

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Abstract

The invention relates to a traditional Chinese medicine for treating the coronary heart disease. The traditional Chinese medicine consists of panax notoginseng saponins and breviscapine, wherein the optimal ratio of panax notoginseng saponins to breviscapine is 2 to 5. The traditional Chinese medicine has the beneficial effect that under the synergistic effect, the better medicinal effect can be achieved and is obviously better than that of a single medicine.

Description

technical field [0001] The invention belongs to the technical field of medicines and relates to a traditional Chinese medicine for treating coronary heart disease. Background technique [0002] Coronary heart disease is a cardiovascular disease with a high incidence rate, and has become a frequently-occurring and common disease that endangers human health. During the attack, the patient feels paroxysmal dull pain or colic in the left front chest or sternal region. Its acute attack has a high mortality rate, and repeated attacks can easily cause arrhythmia or heart failure, which has attracted widespread attention in clinical practice. [0003] The key to the treatment of coronary heart disease is to rebalance the supply and consumption of oxygen. The treatment methods can be divided into two categories, one is to reduce myocardial oxygen consumption, and the other is to improve coronary blood flow. At present, most of the drugs used clinically are chemical drugs, which hav...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61P9/10A61K31/7048
Inventor 不公告发明人
Owner SUZHOU FAMO BIOLOGICAL TECH
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