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A kind of surface heparinized cellulose ester liquid crystal material and its preparation method and application

A technology of liquid crystal materials and cellulose, which is applied in the direction of liquid crystal materials, chemical instruments and methods, etc., can solve the problems of surface liquid crystal state structure change, deformation, and insufficient stability of small molecule liquid crystal domains, etc., and achieve the reduction of interfacial tension, mature technology and high efficiency. Effect of anticoagulant properties

Active Publication Date: 2014-10-29
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The main reason is that the small-molecule liquid crystal domains are not stable enough, and will be deformed (including size and orientation) by the external environment, resulting in changes in the liquid crystal state structure on the surface of the material. Relationship-Based Molecular Design of Biomaterials

Method used

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  • A kind of surface heparinized cellulose ester liquid crystal material and its preparation method and application
  • A kind of surface heparinized cellulose ester liquid crystal material and its preparation method and application
  • A kind of surface heparinized cellulose ester liquid crystal material and its preparation method and application

Examples

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Effect test

Embodiment 1

[0035] (1) Preparation of acryloylated-octanoylated-hydroxypropyl cellulose ester liquid crystal: 2g hydroxypropyl cellulose (M W =100,000, purchased from Aldrich) was dissolved in acetone solution; after complete dissolution, 1mL of acryloyl chloride was added dropwise to it, and reacted at 55°C for 4h, after the reaction was completed, 200mL of deionized water was added to the mixed solution to precipitate the product, and stirred for 5h After that, let it stand for 15 minutes, remove the aqueous solution, dissolve the precipitated product in acetone, then add 200 mL of deionized water to precipitate the precipitated product, stir for 5 hours, let it stand for 15 minutes, remove the aqueous solution, dissolve the precipitated product in acetone, repeat the above Add deionized water, stir, stand still, remove water, dissolve the precipitate in acetone 5 times, dialyze in deionized water for 48 hours at 25°C, remove residual acryloyl chloride, and dry; then dissolve the obtaine...

Embodiment 2

[0051] (1) Preparation of acryloylated-octanoylated-hydroxypropyl cellulose ester liquid crystal: 1g hydroxypropyl cellulose (M W =200,000, purchased from Aldrich) was dissolved in acetone solution; after complete dissolution, 0.5mL of acryloyl chloride was added dropwise to it, and reacted at 65°C for 3h. After the reaction, 200mL of deionized water was added to the mixed solution to precipitate the precipitated product. After stirring for 5 hours, let stand for 15 minutes, remove the aqueous solution, dissolve the precipitated product in acetone, add 200 mL of deionized water to precipitate the precipitated product, stir for 5 hours, let stand for 15 minutes, remove the aqueous solution, dissolve the precipitated product in acetone, Repeat the process of adding deionized water, stirring, standing still, removing water, and dissolving the precipitate in acetone 5 times, then dialyze in ethanol for 8 hours at 25°C to remove residual acryloyl chloride, and dry; then dissolve the...

Embodiment 3

[0054] Preparation of acryloyl-octanoylated-hydroxypropyl cellulose ester liquid crystal: 20g hydroxypropyl cellulose (M W =80,000, purchased from Aldrich) was dissolved in acetone solution; after complete dissolution, 10mL of acryloyl chloride was added dropwise to it, and reacted at 45°C for 6h. After the reaction was completed, 200mL of deionized water was added to the mixed solution to precipitate the product, and stirred for 5h Finally, let it stand for 15 minutes, remove the aqueous solution, dissolve the precipitated product in acetone, add 200 mL of deionized water to precipitate the precipitated product, stir for 5 hours, let stand for 15 minutes, remove the aqueous solution, dissolve the precipitated product in acetone, repeat After the process of adding deionized water, stirring, standing still, removing water, and dissolving the precipitate in acetone three times, dialyze in tetrahydrofuran for 8 hours at 25°C to remove residual acryloyl chloride and dry; then disso...

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Abstract

The invention belongs to the field of biological materials and discloses a surface-heparinized cellulose ester liquid crystal material and a preparation method and application thereof. The preparation method of the liquid crystal material comprises the following steps of: (1) preparation of acryloyl-octanoyl-hydroxy propyl cellulose ester liquid crystal: dissolving hydroxy propyl cellulose into an acetone solution, adding acryloyl chloride and reacting; after the reaction is over, cleaning the obtained mixed solution for 3-5 times, and dialyzing and drying; dissolving the obtained product in acetone, dropwise adding octanoyl chloride and reacting; and cleaning, dialyzing and drying to obtain acryloyl-octanoyl-hydroxy propyl cellulose ester; and (2) preparation of surface-heparinized cellulose ester liquid crystal material: dissolving the acryloyl-octanoyl-hydroxy propyl cellulose ester liquid crystal in tetrahydrofuran, fetching the solution to form a film, then adding a sodium hydroxide solution of heparin sodium, reacting and cleaning to obtain the surface-heparinized cellulose ester liquid crystal material.

Description

technical field [0001] The invention belongs to the field of biological materials, and in particular relates to a surface heparinized cellulose ester liquid crystal material, a preparation method and an application. Background technique [0002] For medical devices in contact with blood, it is required that they do not cause blood coagulation and platelet adhesion and coagulation, and do not destroy the formed components in the blood, such as hemolysis, when in contact with blood, that is, they have blood compatibility. The blood compatibility of medical devices is directly related to the effect of its clinical use. For decades, the development of new thrombus-free biomaterials has been a very challenging topic in the field of biomaterials, and it is also a core technical issue for medical devices. [0003] Liquid crystal (LC) is an intermediate phase between the liquid phase and the solid phase, which not only has the fluidity and continuity of liquid, but also has the ord...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J7/12C08L1/32C08B13/00C09K19/38
Inventor 屠美查振刚曾戎赵巨鹏赵剑豪
Owner JINAN UNIVERSITY
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