Phloroglucinol glucoside derivatives and preparation method thereof

A technology of phloroglucinol galactose and lactose, which is applied in the field of sugar engineering, can solve the problems of unstable photolysis and poor water solubility, and achieve the effect of increasing water solubility and stability and expanding the scope of application
CN103333936AActive Publication Date: 2013-10-02SHANDONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANDONG UNIV
Publication Date
2013-10-02

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Abstract

The invention relates to phloroglucinol glucoside derivatives and a preparation method thereof. The preparation method is characterized in that galactosylated modification is carried out on phloroglucinol by using phloroglucinol as a raw material, a low-cost lactose substrate as a galactosyl donor and glycosidase modified by molecules originated from microorganisms as a tool enzyme so as to synthesize multiple phloroglucinol galactoside derivatives. Compared with the raw material phloroglucinol, the synthesized phloroglucinol galactoside derivatives have the advantages that the synthesized phloroglucinol galactoside derivatives contain galactosyl, the water solubility and the stability are improved, the application range is widened, and the synthesized phloroglucinol galactoside derivatives can serve as new chemical synthesis intermediates to be used for deriving and synthesizing new high value-added compounds.
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Description

technical field

[0001] The invention relates to phloroglucinol glycoside derivatives and a preparation method thereof, in particular to a method for synthesizing phloroglucinol galactoside by using β-galactosidase mutant enzymes, and belongs to the technical field of glycoengineering. technical background

[0002] Phloroglucinol (1,3,5-trihydroxybenzene) is an excellent pharmaceutical product, which has been widely used in antibacterial, inhibition of spleen tyrosine activating enzyme, and apple preservation. In recent years, this compound has also become a new type of myotropic non-atropine non-papaverine pure smooth muscle antispasmodic drug, and its injection has been widely used clinically in France and other European countries, and has become the first choice drug for the treatment of spasmodic pain. In addition, phloroglucinol is also an important fine chemical product, which can be used as an intermediate in drug synthesis for the preparation of flavones, isoflavones ...

Claims

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