Rhizoma alismatis dropping pill and preparation method thereof

A technology of Alisma and dripping pills, which is applied in the fields of pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc. It can solve the problems of single dosage forms and inability to satisfy patients, achieve short dissolution time limit and easy control of process conditions , rapid effect

Active Publication Date: 2013-10-30
吴水生
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, both at home and abroad have begun to pay attention to the development and utilization of Alisma

Method used

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  • Rhizoma alismatis dropping pill and preparation method thereof
  • Rhizoma alismatis dropping pill and preparation method thereof
  • Rhizoma alismatis dropping pill and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The preparation method of Alisma dripping pills of the present invention comprises the following steps:

[0031] Step 1: Take 100g of Alisma medicinal material and grind it, take it through a 40-mesh sieve, add 85% ethanol 12 times the weight of the Alisma raw material, reflux extraction twice, each for 40 minutes, filter, combine the extracts, concentrate the filtrate under reduced pressure, and inject it into the macropore Adsorption resin column, the upper column material is Tianjin Nankai D101 macroporous adsorption resin; first wash away the water-soluble components with 30% ethanol, then elute the total alisitol with 70% ethanol, collect the eluted part of 70% ethanol, and depressurize Concentrate to an extract to obtain Alisma extract.

[0032] The Alisma Alisma extract and matrix are mixed into mixture A, and the matrix is ​​polyethylene glycol 4000 and polyethylene glycol 6000, and the weight of polyethylene glycol 4000 added is 100 g, polyethylene glycol 6000 ...

Embodiment 2

[0035] The preparation method of Alisma dripping pills of the present invention comprises the following steps:

[0036] Step 1: Take 100g of Alisma medicinal material and grind it, take it through a 40-mesh sieve, add 85% ethanol 12 times the weight of the Alisma raw material, reflux extraction twice, each for 40 minutes, filter, combine the extracts, concentrate the filtrate under reduced pressure, and inject it into the macropore Adsorption resin column, the upper column material is Tianjin Nankai D101 macroporous adsorption resin; first wash away the water-soluble components with 30% ethanol, then elute the total alisitol with 70% ethanol, collect the eluted part of 70% ethanol, and depressurize Concentrate to an extract to obtain Alisma extract.

[0037] The Alisma Alisma extract was mixed with a base to form a mixture A, and the base was polyethylene glycol 4000, and the weight of the added polyethylene glycol 4000 was 300 g.

[0038]Step: 2: Heat the mixture A in step 1...

Embodiment 3

[0040] The preparation method of Alisma dripping pills of the present invention comprises the following steps:

[0041] Step 1: Take 100g of Alisma medicinal material and grind it, take it through a 40-mesh sieve, add 85% ethanol 12 times the weight of the Alisma raw material, reflux extraction twice, each for 40 minutes, filter, combine the extracts, concentrate the filtrate under reduced pressure, and inject it into the macropore Adsorption resin column, the upper column material is Tianjin Nankai D101 macroporous adsorption resin; first wash away the water-soluble components with 30% ethanol, then elute the total alisitol with 70% ethanol, collect the eluted part of 70% ethanol, and depressurize Concentrate to an extract to obtain Alisma extract.

[0042] The Alisma Alisma extract was mixed with a base to form a mixture A, and the base was polyethylene glycol 6000, and the weight of the added polyethylene glycol 6000 was 400 g.

[0043] Step: 2: Heat the mixture A in step ...

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Abstract

The invention relates to the field of Chinese herbal preparations and particularly relates to a rhizoma alismatis dropping pill and a preparation method thereof. The technical scheme is as follows: the invention provides the preparation method of the rhizoma alismatis dropping pill, and the method comprises the following steps of: 1, smashing a rhizoma alismatis raw material, extracting the raw material by using ethanol, absorbing the raw material by using macroporous adsorption resin, eluting the raw material by using ethanol, carrying out vacuum concentration until the raw material becomes an extract to obtain a rhizoma alismatis extract, and mixing the rhizoma alismatis extract with a matrix to form a mixture A, wherein the matrix is polyethylene glycol 4000 or polyethylene glycol 6000 or a mixture of the polyethylene glycol 4000 and the polyethylene glycol 6000, and the weight ratio of the rhizoma alismatis raw material to the matrix is 1:4; and 2, heating the mixture A in the step 1 to obtain rhizoma alismatis extract and matrix contained meltwater, uniformly mixing the meltwater, and placing the meltwater on a pill dropping machine for preparing the dropping pill. The prepared rhizoma alismatis dropping pill has the beneficial effects of rapid curative effect, high bioavailability, convenience and simplicity in operation of the preparation process, easiness for controlling the process condition and stable quality.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to Alisma dripping pills and a preparation method thereof. Background technique [0002] Traditional Chinese medicine dripping pills can meet modern preparations "three effects" (high-efficiency, quick-acting, long-acting), "three small" (low toxicity, small reaction, small dosage), "five conveniences" (production, transportation, use, carrying, etc.) , safekeeping) and other advantages are accepted by the people. Moreover, with the accelerated pace of modern life, patients have higher and higher demand for dosage forms. Traditional dosage forms can no longer meet the requirements. The development of traditional Chinese medicine preparations is a historical trend. Dropping Pills just adapted to this trend, opened up a new path for traditional Chinese medicine formulations with its unique advantages, and changed the world's prejudice against traditional Chine...

Claims

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Application Information

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IPC IPC(8): A61K36/884A61K9/20A61P1/16A61P3/06A61P3/10A61P7/10A61P9/10A61P9/12A61P13/04A61P13/12A61P31/04A61P37/08A61P37/02A61K125/00
Inventor 吴水生李小艳宋煜
Owner 吴水生
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