Preparation method of 2-chloro-4-bromophonel with high purity

Abstract

The invention discloses a preparation method of 2-chloro-4-bromophonel with high purity. The preparation method comprises the following steps of mixing and uniformly stirring o-chlorophenol and a locating nanocatalyst, meanwhile, cooling, and adding Br2 to carry out bromination reaction to obtain a product, wherein the locating nanocatalyst is hydrochloride of a transition element. The locating nanocatalyst is a mixture of copper chloride, zinc chloride and silver chloride with the mass ratio of (1-3): (1-8): (1-2). The locating nanocatalyst is used in the preparation method of the 2-chloro-4-bromophonel, so that the purity of the obtained 2-chloro-4-bromophonel is increased from 94% to 97.5%, fewer byproducts are generated, and the yield is very high and can be up to over 97%.

Description

Technical field

[0001] The invention relates to a method for preparing high-purity 2-chloro-4-bromophenol. Background technique

[0002] 2-Chloro-4-bromophenol, an intermediate for the pesticide profenofos, can also be used in other organic synthesis. 2-Chloro-4-bromophenol is an intermediate of the ternary asymmetric organophosphorus insecticide profenofos. High-purity 2-chloro-4-bromophenol is used to synthesize high-quality profenofos technical.

[0003] However, the existing 2-chloro-4-bromophenol production technology can only produce products with a purity of about 94%. The reason is that the production of 2-chloro-4-bromophenol contains 2-chloro-6-bromophenol and more Brominated by-products, the by-products in these raw materials will reduce the purity and at the same time the yield will be affected. Summary of the invention

[0004] The technical problem to be solved by the present invention is to provide a method for preparing high-purity 2-chloro-4-bromophenol, which ha...