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Application of Sarcaboside A to medicament for treatment of rheumatoid osteoarthritis

An arthritic and rheumatoid technology, applied in the application field of Sarcaboside A in the treatment of rheumatoid arthritis, can solve problems such as poor selectivity of action, ulcers, and damage to the gastrointestinal mucosa, and achieve outstanding substantive characteristics and inhibitory activity. strong effect

Inactive Publication Date: 2013-11-20
丁圣雨
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, for rheumatoid arthritis, non-steroidal anti-inflammatory drugs (diclofenac, aspirin, etc.) and immunosuppressants (6-mercaptopurine, etc.) Gastrointestinal mucosa leads to peptic ulcer, which has poor selectivity and is easy to induce infection, etc.

Method used

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  • Application of Sarcaboside A to medicament for treatment of rheumatoid osteoarthritis
  • Application of Sarcaboside A to medicament for treatment of rheumatoid osteoarthritis
  • Application of Sarcaboside A to medicament for treatment of rheumatoid osteoarthritis

Examples

Experimental program
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Effect test

Embodiment 1

[0012] Embodiment 1: The preparation of compound SarcabosideA tablet involved in the present invention:

[0013] Get 20 grams of compound Sarcaboside A, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.

Embodiment 2

[0014] Embodiment 2: the preparation of compound SarcabosideA capsule involved in the present invention:

[0015] Get 20 grams of compound Sarcaboside A, add conventional adjuvants for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0017] Experimental example 1, the influence of Sarcaboside A of the present invention on rat adjuvant arthritis

[0018] Grind Mycobacterium casei (Difco) and mix it with liquid paraffin to make 10mg / ml, and make Freund's complete adjuvant after autoclaving. Male SD rats were intradermally injected with 50ul of the above-mentioned adjuvant in the right hind paw, and at the same time, injected 50ul intradermally at the tail about 3cm away from the base of the tail. The difference of , represents the degree of swelling. On the 16th day after the injection of the adjuvant, the swelling of the left hind foot of the rats was obvious. The rats were divided into groups according to the degree of swelling and body weight. The experimental group was orally given Sarcaboside A5.0, 10.0, 20.0 mg / kg of the present invention, and the positive control group was orally given diclofenac 10 mg / kg, the control group was given equal volume of distilled water, once a day, for 7 consecutive days...

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Abstract

A Sarcaboside A for treatment of immune-inflammation is used in preparation of medicaments for treating rheumatoid osteoarthritis. Seldane and diclofenac sodium are used as contrasts to prove the clear curative effect of the Sarcaboside A. The application of Sarcaboside A to the preparation of medicaments for the treatment of rheumatoid osteoarthritis involved in the invention is disclosed for the first time. As the Sarcaboside A has a novel skeleton type and unimaginably strong activity in inhibition of rheumatoid osteoarthritis, no other compound can give any enlightenment. The invention has outstanding substantive distinguishing features and makes substantial progress in control of rheumatoid osteoarthritis.

Description

technical field [0001] The invention relates to the application of Sarcaboside A in the preparation of medicines for treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis is a clinical common disease and frequently-occurring disease. Rheumatoid arthritis belongs to autoimmune disease and belongs to the category of immune inflammation. At present, for rheumatoid arthritis, non-steroidal anti-inflammatory drugs (diclofenac, aspirin, etc.) and immunosuppressants (6-mercaptopurine, etc.) Gastrointestinal mucosa leads to peptic ulcer, which has poor selectivity and is easy to induce infection. Therefore, compounds with well-defined components, controllable quality, safety and high efficiency have potential value in the development of drugs for rheumatoid arthritis. [0003] The compound Sarcaboside A involved in the present invention is a new skeleton compound published in 2012 (Li, X.etal., 2012.TwoNew-SkeletonCompoundsfromSarcandralabra.HelveticaCh...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P19/02A61P29/00
Inventor 丁圣雨
Owner 丁圣雨
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