Surface comblike polymer hydrophilic modified artificial lens and preparation method thereof

A technology of intraocular lens and comb polymer, which is applied in the direction of intraocular lens, eye implant, coating, etc., can solve the problems of expensive antibody drugs, affecting application value, toxic and side effects, etc., and achieve good anti-adhesion characteristics , good anti-adhesion properties, high biocompatibility

Active Publication Date: 2013-11-27
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above-mentioned drug-loaded intraocular lens can inhibit the proliferation of lens epithelial cells relatively well, there are also some problems: while the loaded chemical drugs inhibit the proliferation of lens epithelial cells, they also inevitably affect corneal endothelial cells, iris, Other cells around the lens, such as ciliary body epithelial cells and retinal nerve cells, produce toxic and side effects; although loaded antibody drugs reduce the toxic and side effects on non-target cells, antibody drugs are expensive and easy to prepare, disinfect, store and Inactivation during transportation affects its practical application value

Method used

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  • Surface comblike polymer hydrophilic modified artificial lens and preparation method thereof
  • Surface comblike polymer hydrophilic modified artificial lens and preparation method thereof
  • Surface comblike polymer hydrophilic modified artificial lens and preparation method thereof

Examples

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Embodiment 1

[0030] Firstly, take a clean intraocular lens, and use amino functional group-containing silane coupling agent surface treatment to bring amino groups on the surface: choose a hard intraocular lens, its material can be polymethyl methacrylate, immerse to 1×10 -5 mol / L γ-aminopropyltriethoxysilane aqueous solution, hydrolyzed for 3 hours, the surface of the intraocular lens material is covered with amino groups, washed with water, and dried with nitrogen gas for later use.

[0031] Next, the RAFT chain transfer agent containing carboxyl functional groups is grafted by chemical methods: after surface amination, it is immersed in the chain transfer agent containing carbodiimide (EDC), N-hydroxysuccinimide (NHS) and carboxyl groups. Thiobenzoates. This example takes 4-cyano-4-(phenylthioformylthio)pentanoic acid (CPCTTP for short) as an example, where EDC: 3mg / mL; NHS: 6mg / mL, CPCTTP: 2mg / mL, at room temperature Stirring was continued for 2 hours, and the RAFT reagent CPCTTP was...

Embodiment 2

[0036] First, take a clean intraocular lens, and make the surface with amino groups through the surface treatment of silane coupling agent containing amino functional groups: choose soft intraocular lens, its material is polyhydroxyethyl methacrylate hydrogel, immerse to 1×10 -5 mol / L γ-aminopropylmethyldiethoxysilane, hydrolyzed for 3 hours, the surface of the intraocular lens material is covered with amino groups, washed with water, and dried with nitrogen gas for later use.

[0037]Next, the RAFT chain transfer agent containing carboxyl functional groups is grafted by chemical methods: after surface amination, it is immersed in the chain transfer agent containing carbodiimide (EDC), N-hydroxysuccinimide (NHS) and carboxyl groups. Thiobenzoates. This example takes 2-(dodecyltrithiocarbonate)-2-methylpropionic acid (DDMAT for short) as an example, where EDC: 3mg / mL; NHS: 6mg / mL, DDMAT: 2mg / mL , kept stirring at room temperature for 2 hours, and the RAFT reagent DDMAT wa...

Embodiment 3

[0042] First, take a clean intraocular lens, and use amino functional group-containing silane coupling agent surface treatment to bring amino groups on the surface: choose a soft intraocular lens, and its material is polydimethylsiloxane PDMS silicone rubber. Immersion to 1×10 -5 mol / L γ-aminopropyltrimethoxysilane aqueous solution, hydrolyzed for 3 hours, the surface of the intraocular lens material is covered with amino groups, washed with water, and dried with nitrogen gas for later use.

[0043] Next, the RAFT chain transfer agent containing carboxyl functional groups is grafted by chemical methods: after surface amination, it is immersed in the chain transfer agent containing carbodiimide (EDC), N-hydroxysuccinimide (NHS) and carboxyl groups. Thiobenzoates. This example takes 2-(dodecyltrithiocarbonate)-2-methylpropionic acid (abbreviated as DTMP) as an example, where EDC: 3mg / mL; NHS: 6mg / mL, DTMP: 2mg / mL , kept stirring at room temperature for 2 hours, and the RAFT a...

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Abstract

The invention relates to a surface comblike polymer hydrophilic modified artificial lens and a preparation method thereof. The preparation method of the surface comblike polymer hydrophilic modified artificial lens comprises the following process steps of carrying out surface treatment on a clean artificial lens by using an amino functional group contained silane coupling agent to enable the surface of the clean artificial lens to have an amino group; grafting a carboxyl functional group contained RAFT (Reversible Addition-Fragmentation Transfer) chain transfer agent on the artificial lens by using a chemical method; and carrying out in-situ polymerization on a hydrophilic monomer molecule on the surface of the artificial lens by using an RAFT polymerization reaction method initiated on the surface of the artificial lens to form a hydrophilic comblike polymer to obtain the surface comblike polymer hydrophilic modified artificial lens. The surface comblike polymer hydrophilic modified artificial lens has the advantages that the condition that the artificial lens has toxic and side effects to non-targeting cells when being applied to a traditional drug coating is avoided, and the artificial lens with high biocompatibility is obtained.

Description

technical field [0001] The invention relates to the field of medical implant materials and device surface modification, in particular to an intraocular lens with a surface comb polymer hydrophilically modified and a preparation method thereof. Background technique [0002] Cataract A blinding eye disease. Clinically, phacoemulsification combined with intraocular lens implantation is mainly used to treat cataract. However, the intraocular lens prepared from materials such as polymethyl methacrylate, polyhydroxyethyl methacrylate hydrogel, and silicone rubber widely used at present generally has foreign body reactions after implantation in human eyes. After intraocular lens implantation, the lens capsule becomes opacified again, also known as after-onset cataract, which is the main complication that seriously affects the visual recovery of patients after intraocular lens implantation. In general, the incidence rate of cataract after 1 year after cataract surgery in adults is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61F2/16C08F293/00C08F220/10C08F220/54C08F220/56
Inventor 林全愧唐俊梅陈浩
Owner WENZHOU MEDICAL UNIV
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