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Watermelon emulsum toothpaste and preparation method thereof

A watermelon cream and toothpaste technology, which is applied in dentistry, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems of destroying the acid-base balance of toothpaste, drying of toothpaste, and difficulty in extrusion. Stable quality effect

Active Publication Date: 2015-04-01
桂林三金日化健康产业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Since watermelon cream is an alkaline substance, when it is added to toothpaste and mixed with abrasive silica, it will easily destroy the acid-base balance of the toothpaste itself, easily cause water loss, and the toothpaste paste will easily dry out and be difficult to squeeze out.

Method used

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  • Watermelon emulsum toothpaste and preparation method thereof
  • Watermelon emulsum toothpaste and preparation method thereof
  • Watermelon emulsum toothpaste and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0066] Experimental example 1, watermelon cream toothpaste stability investigation

[0067] According to the national standard GB8372-2008, put the watermelon frost toothpaste described in Examples 1-16 and Test Examples 1-4 in the refrigerator at -8°C, take it out after 8 hours, and then put it in a constant temperature incubator at 45±1°C for 8 hours Take it out, place it at room temperature for 4 hours, check the paste, and investigate its stability. The results are shown in Table 2.

[0068] Table 2, watermelon frost toothpaste stability test investigation result

[0069]

discoloration

smelly

flatulence

consistency change

separate water

Dry and hard

pH

Example 1

none

none

none

none

none

none

6.5

Example 2

none

none

none

none

none

none

6.5

Example 3

none

none

none

none

none

none

6.5

Example 4

none

...

experiment example 2

[0073] Experimental example 2, the effect of watermelon cream toothpaste on guinea pig gingival swelling induced by phosphate histamine

Embodiment 1 and Embodiment 2

[0074] Test product: embodiment 1 of the present invention and embodiment 2 watermelon cream toothpaste

[0075] Experimental materials: Fuocinonolone ointment and normal saline were purchased from Nanning Pharmaceutical Company.

[0076] Animals: Kunming mice, normal grade, weighing 18-22 g; guinea pigs, normal grade, weighing 180-220 g, provided by the Animal Center of Guangxi University of Traditional Chinese Medicine.

[0077] Get 40 guinea pigs, be randomly divided into watermelon cream toothpaste high-dose group (watermelon frost toothpaste 10mg / g of embodiment 2), low dose group (watermelon frost toothpaste 1mg / g of embodiment 1), positive control group (fluocinolone acetate Ointment 2.5mg / bottle) blank control group (vehicle) in total 4 groups, 10 rats in each group. Each group applied toothpaste to the mandibular gums of anesthetized guinea pigs, q.d. 0.5g each time, and the blank group was coated with the same amount of excipients. Each time the toothpaste was appli...

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Abstract

The invention relates to a watermelon emulsum toothpaste and a preparation method thereof and relates to the field of oral cleaning care. A watermelon emulsum toothpaste body comprises the medicament components including watermelon emulsum, borneol and borneol, wherein the watermelon emulsum accounts for 0.01%-0.10wt%, preferably 0.015wt% of the watermelon emulsum toothpaste body. The invention also relates to the preparation method of the watermelon emulsum toothpaste. Beside the efficacy of cleaning the teeth of a common toothpaste, the watermelon emulsum toothpaste also has the efficacies of preventing endogenous fire, and antianaphylaxis and can alleviate symptoms such as swelling and aching of gums, gingivitis, dental ulcers, ozostomia and the like caused by endogenous fire; the preparation method is simple in process and suitable for industrial production; and the prepared watermelon emulsum toothpaste is stable in quality, is not affected by temperature and humidity and can be stored for a long period of time.

Description

technical field [0001] The invention relates to the field of oral cavity cleaning care, in particular to a toothpaste and a preparation method thereof. Background technique [0002] Toothpaste is a cleaning product commonly used in daily life. Its basic function is to clean teeth, freshen breath and keep oral cavity clean. With the enhancement of global environmental protection and health care awareness, people have higher and higher requirements for toothpaste, requiring it to be non-toxic to the human body and harmless to the environment while having certain efficacy and ease of use. At present, there are many kinds of toothpaste on the market in our country. The common ones are: fluoride toothpaste, Chinese herbal toothpaste, anti-inflammatory toothpaste, hypoallergenic toothpaste and salt toothpaste. Among them, Chinese herbal toothpaste with rich Chinese traditional characteristics is green, natural, safe and unique in efficacy. It complies with the modern people's con...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/97A61K8/34A61K8/19A61Q11/00A61P1/02
Inventor 邹准
Owner 桂林三金日化健康产业有限公司
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