Angle modulation and wavelength modulation surface plasmon resonance (SPR) sharing system

A technology of wavelength modulation and angle modulation, which is applied to the measurement of phase influence characteristics, etc., can solve the problems of angle modulation SPR sensors and wavelength modulation SPR sensors, such as single function, difficult acquisition, low data measurement accuracy and wavelength modulation SPR sensor, etc., to eliminate Influence of unstable light source, improvement of accuracy and sensitivity, effect of improvement of measurement accuracy and sensitivity

Active Publication Date: 2015-05-13
锐光凯奇(镇江)光电科技有限公司
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  • Abstract
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Problems solved by technology

[0005] The present invention aims to solve the problems that the existing angle modulation SPR sensor and wavelength modulation SPR sensor have single function, the angle modulation SPR sensor data measurement accuracy is low, and the wavelength modulation SPR sensor is difficult to realize real-time acquisition of reference spectrum. The invention provides an angle modulation Shared system with wavelength modulation SPR

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  • Angle modulation and wavelength modulation surface plasmon resonance (SPR) sharing system

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specific Embodiment approach 1

[0019] Specific implementation mode one: see figure 1 Describe this embodiment, the angle modulation and wavelength modulation SPR sharing system described in this embodiment, it includes light source 1, reflection prism 2, microscope objective lens 3, slide glass 4, gold film 5, receiver 6, reflection mirror 7 and spectrometer 8;

[0020] The stepper motor is used to drive the reflective prism 2 to move left and right in the plane, the gold film 5 is coated on one side of the slide glass 4, and the gold film 5 is in contact with the object to be measured, and the microscopic objective lens 3 passes the refractive index The matching liquid is coupled with the other side of the slide glass 4; after the light output by the light source 1 is incident on the first end face of the reflective prism 2, two beams of light are formed, wherein the first beam of light is on the first end face of the reflective prism 2 The reflected light formed on one end face, the second beam of light ...

specific Embodiment approach 2

[0028] Specific implementation mode two: see figure 1 To illustrate this embodiment, according to the method for realizing optical path alignment between the light source and the receiver in the angle modulation and wavelength modulation SPR sharing system described in the first embodiment, its specific process is as follows:

[0029] Step 1. Rough adjustment: set the light outlet of the light source 1 and the light inlet of the receiver 6 opposite to each other;

[0030] Step 2, fine adjustment: By adjusting the relative position of the light entrance of the receiver 6 and the light exit of the light source 1, the light intensity received by the receiver 6 reaches the maximum, and the optical path collimation is completed.

[0031] In this embodiment, it is ensured that when the reflective prism 2 is removed, the light emitted by the light source 1 is collimated and incident on the receiver 6 .

specific Embodiment approach 3

[0032] Specific implementation mode three: see figure 1 This embodiment is described. The difference between this embodiment and the angle modulation and wavelength modulation SPR sharing system described in the first embodiment is that the light output by the light source 1 is monochromatic light or broadband light.

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Abstract

The invention discloses an angle modulation and wavelength modulation surface plasmon resonance (SPR) sharing system which relates to the field of optics and aims to solve the problems of function singleness of an existing angle modulation SPR sensor and an existing wavelength modulation SPR sensor, low data measurement accuracy of the angle modulation SPR sensor, difficulty in real-time acquisition of reference spectra of the wavelength modulation SPR sensor and the like. Light output by a light source is emitted to a first end surface of a reflecting prism to form reflected light and transmission light; the reflected light penetrates through a microscope objective, is focused on a gold film, is totally reflected by the gold film, then penetrates through the microscope objective, is reflected by a second end surface of the reflecting prism and then is emitted to a receiver; the transmission light is reflected in the reflecting prism, is transmitted from the first end surface of the reflecting prism, is reflected by a reflecting mirror and is emitted to a spectrometer. The angle modulation and wavelength modulation SPR sharing system is specifically applied to the fields of chemical analysis, biomedicine, environment monitoring, food analysis, medical treatment, pharmacy and the like.

Description

technical field [0001] The invention belongs to the field of SRP sensing and detection. Background technique [0002] The surface plasmon resonance (Surface Plasmon Resonance, SPR) phenomenon is extremely sensitive to the refractive index of the medium (or film layer) in contact with the metal thin film that generates surface plasmons. Based on this characteristic, SPR sensing and detection technology has attracted much attention. , and has been developed rapidly, and has been widely used in biosensing, chemical analysis, drug research and development, food safety, environmental testing, medical diagnosis and other fields. SPR sensors have four modulation methods, namely angle, wavelength, intensity and phase modulation. At present, SPR sensors with a single modulation mode are commonly used and the technology is relatively mature, such as angle modulation SPR sensors, wavelength modulation SPR sensors, etc. And in the traditional angle-modulated SPR sensor, the stepper mo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/41
Inventor 黄妍李松权高来勖刘书钢
Owner 锐光凯奇(镇江)光电科技有限公司
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