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Binder for tablet forming

A technology for adhesives and compression moldings, which is applied in the directions of medical preparations without active ingredients, medical preparations containing active ingredients, and pill delivery.

Inactive Publication Date: 2013-12-11
KYOWA CHEM IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this way, although inorganic alkaline substances have effects that cannot be obtained by neutral substances such as crystalline cellulose, there has not been a magnesium compound that can improve the adhesion of molded articles by adding a small amount

Method used

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  • Binder for tablet forming
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  • Binder for tablet forming

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] The magnesium sulfate aqueous solution and alkali mixture (NaOH:Na 2 CO 3 =18:1) The slurry obtained by the continuous injection reaction is washed with water, dried and pulverized to obtain the Mg(OH) 1.8 (CO 3 ) 0.1 0.13H 2 A binder composed of carbonate-containing magnesium hydroxide particles represented by O. The BET method specific surface area of ​​the obtained adhesive is 251m 2 / g, the average secondary particle size is 12.8 μm, and the angle of repose is 44°.

Embodiment 2

[0098] The magnesium sulfate aqueous solution and alkali mixture (NaOH:Na 2 CO 3 =18:1) The slurry obtained by continuous injection reaction is washed with water, emulsified, and then spray-dried to obtain the Mg(OH) 1.8 (CO 3 ) 0.1 0.18H 2 A spherical binder composed of carbonate-containing magnesium hydroxide particles represented by O. The BET method specific surface area of ​​the obtained adhesive is 237m 2 / g, the average secondary particle size is 153.2 μm, and the angle of repose is 30°.

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Abstract

The present invention relates to a novel binder with high adhesiveness and high fluidity. The binder has a specific surface area of 80-400 m2 / g measured by the BET method, and is formed by the carbonate group-containing magnesium hydroxide particles represented by the formula (1). Mg(OH)[2-x](CO3)[0.5x] mH20 (1),wherein the x and the m satisfy the conditions that the x is not less than 0.02 and not more than 0.7, and the m is mot less than 0 and is not more than 1. According to the binder, even when the binder is formulated together with a disintegrant or a water-soluble excipient, tablet disintegration time cannot be prolonged, the tablet hardness is improved, and the binder can be used for compression tableting directly.

Description

technical field [0001] The present invention relates to a binder added to impart adhesiveness in the manufacture of solid preparations such as pharmaceuticals, foods, and agricultural chemicals, and a compression molded product using the same. Furthermore, the present invention relates to a disintegrable compressed molded product prepared by mixing a binder and a disintegrant or a water-soluble excipient. Background technique [0002] Solid preparations such as pharmaceuticals and foods are often molded by adding a binder (binder) that has the effect of linking powder particles in order to improve the yield failure during production and improve the mechanical strength of the molded product. Examples of binders used in these solid preparations include starch, gelatin, gum arabic, xanthan gum, dextrin, dextran, pullulan, polyvinyl alcohol, polyvinylpyrrolidone, and hydroxypropyl cellulose , hydroxypropyl methylcellulose, methylcellulose, sodium carboxymethylcellulose, crystal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/02A61K9/20A61K47/26A61K47/32A61K47/36A61K47/38
CPCA61K9/2009A61K9/2054A61K31/609A61K9/1611C01F5/24C01P2006/12A61K47/02A61K9/20A61K47/26A61K47/32A61K47/36A61K47/38
Inventor 立藤智子
Owner KYOWA CHEM IND