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Compound sulfamonomethoxine sodium injection and preparation method thereof

A technology of sodium methotrexate and compound sulfonamide, applied in the field of injections, can solve the problems of irritants and consumption of organic solvents, and achieve the effect of reducing usage, cost, and risk of clinical irritation

Active Publication Date: 2013-12-18
四川康而好动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the problems referred to above, the purpose of this invention is to provide a compound sulfamethoxine sodium injection and preparation method thereof, which solves the problem that the existing method consumes a large amount of organic solvent and easily causes the stimulating agent of the body

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Compound sulfamethoxine sodium injection, by weight, its composition is as follows:

[0033] 5 parts of sulfamethoxine sodium; 4 parts of trimethoprim; 0.2 parts of antioxidant; 25 parts of organic solvent; 2 parts of acid regulator; 5 parts of base regulator; 65 parts of water for injection. The organic solvent is a mixture of propylene glycol and polyethylene glycol 400 at a volume ratio of 1:1. The acid regulator is lactic acid. The alkaline regulator is sodium hydroxide. Described antioxidant is sodium thiosulfate.

[0034] Its preparation steps are:

[0035] Step 1: Take 25 parts of fresh water for injection, add antioxidants and stir to dissolve completely;

[0036] Step 2: Add trimethoprim, add acid regulator dropwise, heat to 60°C, stir to dissolve completely;

[0037] Step 3: Add organic solvent, stir and mix evenly, and cool to 30°C;

[0038] Step 4: Add alkaline regulator dropwise to adjust to pH 11.0;

[0039] Step 5: Add sulfamethoxine sodium, stir t...

Embodiment 2

[0043] Compound sulfamethoxine sodium injection, by weight, its composition is as follows:

[0044] 30 parts of sulfamethoxine sodium; 1 part of trimethoprim; 0.4 parts of antioxidant; 45 parts of organic solvent; 1 part of acidic regulator; 1 part of basic regulator; 45 parts of water for injection. The organic solvent is a mixture of propylene glycol and polyethylene glycol 400 at a volume ratio of 1:1. The acid regulator is lactic acid. The alkaline regulator is sodium hydroxide. Described antioxidant is sodium thiosulfate.

[0045] Its preparation steps are:

[0046] Step 1: Take 15 parts of freshly prepared water for injection, add antioxidants and stir to dissolve completely;

[0047] Step 2: Add trimethoprim, add acid regulator dropwise, heat to 80°C, stir to dissolve completely;

[0048] Step 3: Add organic solvent, stir and mix evenly, and cool to 18°C;

[0049] Step 4: Add alkaline regulator dropwise to adjust to pH 9.0;

[0050] Step 5: Add sulfamethoxine sod...

Embodiment 3

[0054] Compound sulfamethoxine sodium injection, by weight, its composition is as follows:

[0055] 20 parts of sulfamethoxine sodium; 3 parts of trimethoprim; 0.3 parts of antioxidant; 35 parts of organic solvent; 1.5 parts of acid regulator; 3 parts of base regulator; 55 parts of water for injection. The organic solvent is a mixture of propylene glycol and polyethylene glycol 400 at a volume ratio of 1:1. The acid regulator is lactic acid. The alkaline regulator is sodium hydroxide. Described antioxidant is sodium thiosulfate.

[0056] Its preparation steps are:

[0057] Step 1: Take 20 parts of fresh water for injection, add antioxidants and stir to dissolve completely;

[0058] Step 2: Add trimethoprim, add acid regulator dropwise, heat to 70°C, stir to dissolve completely;

[0059] Step 3: Add organic solvent, stir and mix evenly, and cool to 25°C;

[0060] Step 4: Add alkaline regulator dropwise to adjust to pH 10.0;

[0061] Step 5: Add sulfamethoxine sodium, sti...

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PUM

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Abstract

The invention discloses a compound sulfamonomethoxine sodium injection and a preparation method thereof. The compound sulfamonomethoxine sodium injection comprises, by weight, 5-30 parts of sulfamonomethoxine sodium, 1-4 parts of trimethoprim, 0.2-0.4 part of antioxidants, 25-45 parts of organic solvents, 1-2 parts of acid form modifiers, 1-5 parts of alkali form modifiers and 45-65 parts of water for injection. Through the technological improvement of the compound sulfamonomethoxine sodium injection, the using quantity of organic solvents is reduced, cost can be greatly lowered, and the risk for causing clinical irritation is lowered.

Description

technical field [0001] The invention belongs to the field of injections, in particular to a compound sulfamethoxine sodium injection and a preparation method thereof. Background technique [0002] Sulfamethoxine sodium: its mechanism of action is to inhibit the growth and reproduction of bacteria by inhibiting the metabolism of folic acid in the bacteria, and compete with PAB for dihydrofolate synthase. It has the strongest antibacterial activity among the sulfonamides, and has a strong inhibitory effect on most Gram-positive and negative bacteria. Bacteria develop resistance to it slowly, and it is mainly used for various diseases caused by sensitive bacteria. The acetylation rate is low, crystalluria is not easy to occur, and the effective blood concentration maintenance time is 24 hours for buffalo, 5.8 hours for pigs, 7 hours for goats, and 2 hours for sheep. [0003] Trimethoprim: The antibacterial spectrum is similar to that of sulfonamides and has stronger activity....

Claims

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Application Information

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IPC IPC(8): A61K31/635A61K9/08A61P31/04A61K31/505
Inventor 钟建
Owner 四川康而好动物药业有限公司
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