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Traditional Chinese medicine composition for treating chronic nephritis proteinuria as well as preparation method and use thereof

A technology for chronic nephritis and proteinuria, which is used in drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients to achieve the effects of reducing clinical symptom scores, reducing medical expenses, and improving quality of life.

Active Publication Date: 2013-12-25
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

"The ancients did not find urinary protein at that time, but from the current point of view, it is speculated that proteinuria in chronic nephritis is closely related to wind evil.

Method used

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  • Traditional Chinese medicine composition for treating chronic nephritis proteinuria as well as preparation method and use thereof
  • Traditional Chinese medicine composition for treating chronic nephritis proteinuria as well as preparation method and use thereof
  • Traditional Chinese medicine composition for treating chronic nephritis proteinuria as well as preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1 Granules

[0034] The traditional Chinese medicine raw materials with the following weight proportions are adopted: 5 grams of Astragalus membranaceus, 5 grams of Zeilan, 5 grams of Mirengen, 5 grams of Shiwei, 5 grams of Qingfengteng, 5 grams of Guijianyu (referring to the daily crude drug dose), through the following Prepared by the method:

[0035] Astragalus, Eupatorium, Mirengen, and Shiwei, add 8 times the amount of ethanol each time, extract 3 times, extract for 1 hour each time, filter, and combine the ethanol extracts; The extraction process of decoction, that is, Qingfengteng and Guijianyu are soaked in 8 times of water each time, soaked for 1 hour, extracted three times, and the water extract is concentrated to a relative density of 1.08-1.12 (80°C), and then purified. The purification method can be ethanol Precipitation method, centrifugation method or chitosan clarification method; the ethanol extracts of Astragalus, Eupatorium, Mirengen, Shiw...

Embodiment 2

[0036] Embodiment 2 Granules

[0037] The traditional Chinese medicine raw materials with the following weight proportions are used: 60 grams of astragalus, 30 grams of Zelan, 50 grams of Mirengen, 45 grams of Shiwei, 45 grams of Qingfengteng, and 45 grams of Guijianyu (referring to the daily crude drug dose). Prepared by:

[0038] Astragalus, Eupatorium, Mirengen, and Shiwei, add 12 times the amount of ethanol each time, extract 3 times, extract 2 hours each time, filter, and combine the ethanol extracts; The extraction process of decoction, that is, Qingfengteng and Guijianyu are soaked in 10 times of water each time, soaked for 2 hours, extracted three times, and the water extract is concentrated to a relative density of 1.08-1.12 (80°C), and then purified. The purification method can be ethanol Precipitation method, centrifugation method or chitosan clarification method; the ethanol extracts of Astragalus, Eupatorium, Mirengen, Shiwei ethanol extracts and other medicinal ...

Embodiment 3

[0039] Example 3 tablet

[0040] The traditional Chinese medicine raw materials with the following weight proportions are used: 10 grams of Astragalus membranaceus, 10 grams of Zelan, 10 grams of Mirengen, 10 grams of Shiwei, 6 grams of Qingfengteng, and 6 grams of Guijianyu (referring to the daily crude drug dose). Prepared by:

[0041] Astragalus, Eupatorium, Mirengen, and Shiwei, add 10 times the amount of ethanol each time, extract 3 times, extract for 1.5 hours each time, filter, and combine the ethanol extracts; The extraction process of decoction, that is, Qingfengteng and Guijianyu are soaked in 9 times of water each time for 1.5 hours, extracted three times, and the water extract is concentrated to a relative density of 1.08-1.12 (80°C), and then purified. The purification method can be ethanol Precipitation method, centrifugation method or chitosan clarification method; the ethanol extracts of Astragalus, Eupatorium, Mirengen, Shiwei ethanol extracts and other medic...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating chronic nephritis proteinuria and a preparation method thereof. According to the traditional Chinese medicine theory that dampness is caused by deficiency, stasis is caused by deficiency and edema is caused by blood stasis as well as the dampness can be overcome by wind, qi and blood can be dredged, the traditional Chinese medicine composition is prepared from the following material medicine components in parts by weight: 5-60 parts of astragalus membranaceus, 5-30 parts of herba lycopi, 5-50 parts of coix seed roots, 5-45 parts of pyrrosia lingua, 5-45 parts of caulis sinomenii and 5-45 parts of euonymus alatus. The traditional Chinese medicine composition disclosed by the invention is clinically proved to have effects of improving clinical symptoms of a chronic nephritis patient, lowering 24-hour urine protein ration, protecting renal function, adjusting renal blood dynamic indexes and cellular immunity, and the like. Qi-blood theory of the traditional Chinese medicine is interpreted by the modern experimental technique. The traditional Chinese medicine composition is safe, effective, cheap, and suitable for long-term use of spleen and kidney qi-deficiency type and damp turbidity stasis obstruction type chronic nephritis patients, and has extensive clinical application value and guiding significance.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating chronic nephritis proteinuria, a preparation method and application thereof. Background technique [0002] Chronic glomerulonephritis (CGN), referred to as chronic nephritis (CGN), is a group of diseases that originate in the glomerulus composed of various causes and pathological types, and is the most common cause of end-stage renal failure (ESRD). The etiology accounts for about 54.4% in our country. Due to the long course of the disease, chronic nephritis is prone to repeated changes, and the patients are affected to varying degrees in terms of the functional level of the various systems of the body, the psychological state, and the ability to adapt to the social environment. The serious decline in quality of life has become an important fa...

Claims

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Application Information

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IPC IPC(8): A61K36/8994A61K36/899A61P13/12
Inventor 王琛郑平东何立群杨雪军高建东兰天鹰
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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