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A kind of preparation method of film coating premix

A technology of film coating and premix, which is applied in the field of drug coating, can solve the problems of long production cycle, extended time, poor quality controllability, etc., and achieve the effect of shortening the production cycle

Active Publication Date: 2015-11-25
BEIJING YINGMAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The processing technology of traditional film coating premix generally includes: mixing, drying, premixing, crushing, sieving, total mixing and other steps. The solubility is better at 80-120 mesh, but when it reaches 80-120 mesh, the crushing time will increase, which prolongs the production time. The whole process will take at least 10-12 hours, and more processes are needed. There are many workers, and the production cycle is long, which is the main reason for the high production cost

Method used

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Examples

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Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: The preparation method of a film coating premix developed by the present invention includes the following steps: (1) Mix the raw material of the premix with an ethanol solution, and stir for 20-40 minutes until all the materials are dissolved and dispersed uniformly. Yes, the raw materials of the premix include film-forming materials, auxiliaries, and colorants; the film-forming materials included in the film-coating premix generally include cellulose derivatives, polyvinyl acetate, etc. Glyceryl acetate, polyvinyl alcohol, etc., colorants are lakes of various colors, such as red lakes, yellow lakes, white lakes, purple lakes, blue lakes, etc.

[0013] (2) (2) The raw material processed in step (1) is granulated by a rocking granulator;

[0014] (3) The granules obtained in step (2) are dried by vacuum freeze-drying to obtain the film-coating premix.

[0015] In step (1), the mass concentration of the ethanol solution is 50%, and when every 100 kg of raw ...

Embodiment 2

[0022] Example 2: Using the method of the present invention to prepare a film coating premix, the preparation method includes the following steps: (1) Mix the raw materials of the premix with an ethanol solution, and stir for 20-40 minutes until all the materials are dissolved and dispersed uniformly. The raw materials of the mixture include film-forming materials, auxiliaries, and colorants;

[0023] (2) The raw material processed in step (1) is granulated by a rocking granulator;

[0024] (3) The granules obtained in step (2) are dried by vacuum freeze-drying to obtain the film-coating premix.

[0025] In step (1), the mass concentration of the ethanol solution is 70%, and when every 100 kg of raw materials is mixed with the ethanol solution of this mass concentration, the mass of the ethanol solution is 50 kg.

[0026] In step (2), the rotating speed of the drum in the swing granulator is 50-65 r / min, the screen mesh is 24 mesh sieve, and the particle size of the obtained ...

Embodiment 3

[0032] Embodiment 3: The preparation method of a film coating premix developed by the present invention includes the following steps: (1) Mix the raw material of the premix with an ethanol solution, and stir for 20-40 minutes until all the materials are dissolved and dispersed evenly, that is, Yes, the raw materials of the premix include film-forming materials, auxiliaries, and colorants;

[0033] (2) The raw material processed in step (1) is granulated by a rocking granulator;

[0034] (3) The granules obtained in step (2) are dried by vacuum freeze-drying to obtain the film-coating premix.

[0035] In step (1), the mass concentration of the ethanol solution is 60%, and when every 100 kg of raw materials is mixed with the ethanol solution of this mass concentration, the mass of the ethanol solution is 45 kg.

[0036] In step (2), the rotating speed of the drum in the swing granulator is 50-65 r / min, the screen mesh is 24 mesh sieve, and the particle size of the obtained part...

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Abstract

The invention discloses a preparation method for a thin film coated premix. The preparation method comprises the following steps: (1) mixing raw materials for the premix with an ethanol solution; (2) subjecting the raw materials treated in the step (1) to granulation by using an oscillating granulator; and (3) drying a granule obtained in the step (2) by using a vacuum freeze-drying method so as to obtain the thin film coated premix. The invention has the following advantages: six procedures consisting of mixing, drying, premixing, crushing, sieving and total blending and 10 to 12 hours are needed by a conventional method for preparation of a thin film coated premix with a size of 80 to 120 meshes and good dissolving properties, time for total blending has to be prolonged to realize fine adjustment of a color if the color is nonuniform, but however, only three procedures consisting of mixing, granulation and drying and 3 to 4 hours are needed by the preparation method provided by the invention for preparation of the thin film coated premix with better dissolving properties, and the color of the thin film coated premix needs no adjustment after direct drying.

Description

technical field [0001] The invention belongs to the technical field of drug coating, in particular to a preparation method of a film coating premix. Background technique [0002] The traditional processing technology of film coating premix generally includes: mixing, drying, premixing, pulverizing, sieving, mixing and other steps. There are many processing procedures, long product production cycle, poor quality controllability, and the product particle size generally needs to reach 80-120 mesh has better solubility, but when it reaches 80-120 mesh, the crushing time will increase, which extends the production time. The whole process needs at least 10-12 hours. The number of workers and the long production cycle are the main reasons for the high production cost. SUMMARY OF THE INVENTION [0003] In order to solve the above-mentioned defects such as many production steps and long production cycle when the existing premix is ​​required to obtain better dissolving performance...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K47/10
Inventor 陈佩英
Owner BEIJING YINGMAO PHARMA
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