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Duodenum targeted hollow capsules

A technology of hollow capsules and duodenum, which is applied in the direction of capsule delivery, medical preparations of non-active ingredients, non-effective ingredients of polymer compounds, etc. It can solve the problem of long-term release of drugs in capsules that can only be released in the small intestine of the human body.

Active Publication Date: 2015-07-22
ANHUI HUANGSHAN CAPSULE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These enteric coating materials are good for gastric acid resistance, but they all disintegrate or dissolve in artificial intestinal juice (pH 6.8), and the disintegration or dissolution time is long, and they can only release the drugs in the capsule in the small intestine of the human body, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0014] 1. Preparation of capsule material

[0015] Put gelatin or vegetable glue and water into the mixing kettle, heat and stir to dissolve, filter, adjust the specific gravity (that is, the concentration of the glue), add various colors of food coloring according to the different needs of users, and add a certain amount of sunscreen titanium dioxide, etc., After standing for heat preservation, the air bubbles are removed, and then the capsule material is obtained by dipping, curing and drying into the capsule cap mold on the capsule production line.

[0016] 2. Coating

[0017] Using ethanol or / and acetone as a solvent, polyvinyl alcohol acetate phthalate (referred to as PVAP) is prepared into a coating solution with a concentration of 10%, after at least one coating on the coating line, drying, The duodenum-targeted hollow capsule is made by demoulding, cutting, and nesting.

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PUM

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Abstract

The invention relates to duodenum targeted hollow capsules which are composed of a capsule material of gelatin or vegetable gum, and a coating layer on the outside of a surface material. The capsules are characterized in that the coating layer is polyvinyl acetate phthalate, and mass proportions of the capsule material and the coating layer are respectively 70-80% to 20-30%. The capsules are not disintegrated after more than 2h in artificial gastric juice with a pH value of 2, can be disintegrated in 30min in artificial gastric juice with a pH value of 4, and can be disintegrated in 10-15min in artificial gastric juice with a pH value of 6.8. The hollow capsules can be disintegrated at specific human duodenum parts, and release the medicine in the capsules.

Description

1. Technical field [0001] The invention relates to a hollow capsule of medicinal excipients, in particular to a targeted hollow capsule that is not allowed to disintegrate in the stomach of a human body, but is to be disintegrated rapidly in a specific part of the duodenum of the human body. 2. Background technology [0002] Enteric-coated hollow capsules (capsule shells) refer to the provisions of the 2010 edition of the Chinese Pharmacopoeia: the capsule shells cannot disintegrate in artificial gastric juice (pH value 2) for more than 2 hours, but can be dissolved in artificial intestinal juice (pH value 6.8) within 1 hour. disintegrate or melt. The enteric-coated hollow capsules currently used are all processed and formed from gelatin or vegetable gum and then coated with gastric acid-resistant enteric coating materials. The production process is that gelatin or vegetable peptizing is dissolved into a glue solution and then sent to a capsule production line to form, soli...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/42A61K47/32
Inventor 刘国攀刘松林
Owner ANHUI HUANGSHAN CAPSULE CO LTD