Non-invasive fetal genetic screening by sequencing analysis

A fetal and sequencing technology, applied in the field of non-invasive technology, can solve the problems of sample consumption, differentiation, and digital analysis that do not allow the detection of single nucleotide polymorphisms in fetuses, so as to achieve improved clinical performance and high detection rate Effect
CN103534591AInactive Publication Date: 2014-01-22THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
Publication Date
2014-01-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a non-invasive technique for the differential detection of multiple genotypes and / or mutations for a plurality of target genes in a biological sample containing genetic material from different genomic sources. Methods are conducted using multiplex amplification of a plurality of target sequences from the biological sample, and sequencing is used to detect and enumerate genetic mutations and chromosomal abnormalities at the single nucleotide level.
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Description

[0001] related application

[0002] This patent application claims the benefit of and priority to US Provisional Patent Application Serial No. 61 / 406,809, filed October 26, 2010, which is hereby incorporated by reference in its entirety.

[0003] Statement Regarding Federally Sponsored Research or Development

[0004] This invention was made with United States Government support under agreement OD000251 awarded by the National Institutes of Health. The government has certain rights in this invention. technical field

[0005] The present invention relates to the field of quantitative nucleic acid analysis from biological samples containing genetic material from different genomic sources. More specifically, the present invention provides a non-invasive technique for the differential detection of genotypes in biological samples containing genetic material from different genomic sources. Background technique

[0006] Fetal DNA shed from the placenta can be detected in mate...

Claims

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