Preparation method of raja porosa extract as well as application of raja porosa extract in alcoholic liver protection medicament

A technology of extract and ray, which is applied in the field of application in the preparation of protective drugs against alcoholic liver damage, to achieve the effect of enhancing scavenging ability and enhancing activity

Active Publication Date: 2014-02-12
SHANDONG HAIYU BIOLOGICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The preparation method of the ray extract and its application in the prepara

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0010] Step 1: Preparation of Kong Ray Extract

[0011] Cook the fresh ray, remove the fish meat, rinse the cartilage with water, mince, add NaOH solution according to the mass ratio of solid to liquid at 1:1.5, stir and extract for 4 hours, then adjust the pH to 6-7 with HCl, filter, and put in the filtrate Add NaOH to adjust pH=8.5-9.0, and add compound protease to hydrolyze for 4 h according to the mass ratio of feed liquid to compound protease 1000:1. Heat the hydrolyzate at 80°C for 30 min, add HCl to adjust pH=3, let it stand still, filter the upper layer solution with pumice, add NaOH to adjust pH=10.5, decolorize with hydrogen peroxide and filter, add HCl to the filtrate to adjust pH=7, decompress the filtrate Concentrate to a small volume and dry the precipitate to obtain the ray extract.

[0012] Step 2: preparation of preparation

[0013] (1) Preparation of the capsule preparation of the ray extract of the present invention

[0014] Weigh 100 mg of the ray extrac...

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PUM

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Abstract

The invention discloses a preparation method of a raja porosa extract, and an application of the raja porosa extract in preparing an alcoholic liver protection medicament. The preparation method is characterized by comprising the following steps: boiling fresh raja porosa, subsequently peeling off the meat, washing the soft bone in clean water, crushing the soft bone, adding a NaOH solution according to a material-liquid mass ratio of 1:(1-1.5), stirring and extracting for 4 hours, subsequently adjusting the pH value to be 6 to 7 by using HCl, filtering, adding NaOH into the filtrate to adjust the PH value to be 8.5-9.0, adding compound protease to hydrolyze for 4 hours according to a mass ratio of the material liquid to the compound protease of 1,000:1, heating the hydrolysate for 30 minutes to be 80 DEG C, adding HCl to adjust the pH value to be 2, standing, performing suction filtration on the solution at the upper layer by using kieselguhr, adding NaOH to adjust the pH value to be 10.5, decoloring by using hydrogen peroxide, subsequently filtering, adding HCl into the filtrate to adjust the pH value to be 7, carrying out reduced-pressure concentration on the filtrate to be a small volume, precipitating and drying so as to obtain the raja porosa extract. The raja porosa extract can be used as an alcoholic liver injury protection agent as the activity of an antioxidant enzyme is improved and the cleaning capability of an organism to a peroxidatic reaction product is improved.

Description

technical field [0001] The invention relates to a preparation method of the ray extract and its application in the preparation of protective drugs against alcoholic liver damage. Background technique [0002] At present, alcoholism and addiction have become a global problem. Long-term heavy drinking can cause damage to multiple organs throughout the body, especially to the liver. Chronic alcoholism can lead to symptoms such as alcoholic fatty liver, alcoholic hepatitis, alcoholic cirrhosis, fibrosis, and in severe cases, canceration. At present, for the treatment of alcoholic liver poisoning, many methods include amino acid and glucose infusion, multivitamins, maintenance of water, electrolyte and acid-base balance, etc. In recent years, many researchers have tried to find a method that can effectively prevent and protect the liver from Medicines that lessen the damaging effects of alcohol on the liver. [0003] Kong ray (Raja porosa Günther), commonly known as Laoban fish...

Claims

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Application Information

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IPC IPC(8): A61K35/60A61K9/48A61K9/20A61P1/16
Inventor 高华刘坤石振艳
Owner SHANDONG HAIYU BIOLOGICAL CO LTD
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