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Thesium granule with high stability and preparation method thereof

A granule and stability technology, which is applied in the field of traditional Chinese medicine preparations, can solve the problems that the main component kaempferol is easy to degrade, not easy to be taken by patients with stomach problems, and poor stability, so as to improve accumulation and physical properties, stabilize granules, and increase extraction rate Effect

Active Publication Date: 2015-06-03
九华华源药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The products already on the market include capsules and tablets, but these two dosage forms are suitable for children to take, and after the capsule dissolves in the stomach, it is easy to produce excessive local concentration, which increases the irritation, so it is not easy for patients with severe stomach problems take
[0005] Conventional barley preparations have the problems of poor stability, the main component kaempferol is easy to degrade, and the friability is not good. During the packaging process, the particles are easily broken

Method used

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  • Thesium granule with high stability and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Prepare the following raw materials:

[0031] Thyme 100Kg, micropowder silica gel 1Kg, sucrose 10Kg, dextrin 15Kg. The particle size of the micropowdered silica gel is between 300-400 mesh.

[0032] Prepare Bairui Granules according to the following steps:

[0033] S1: Take thyme grass and add ethanol water solution to decoct, add the ethanol water solution of 5 times the weight of the thyme grass for the first time, heat to reflux, decoct for 3 hours, add the ethanol water solution of 4 times the weight of the thyme grass for the second time, and heat Reflux and decoct for 2 hours;

[0034] S2: Filter the decoction, combine the filtrates, concentrate under reduced pressure, recover ethanol until the relative density is 1.22 (80°C), and let cool;

[0035] S3: Add water 5 times the weight of Thyme chinensis to the decoction obtained in step S2, and stir well; then add water 3 times the weight of Thyme chinensis, and stir well;

[0036] S4: Stand still for 16 hours, f...

Embodiment 2

[0040] Prepare the following raw materials:

[0041] Thyme 120Kg, micropowder silica gel 3Kg, sucrose 15Kg, dextrin 20Kg. The particle size of the micropowdered silica gel is between 300-400 mesh.

[0042] Prepare Bairui Granules according to the following steps:

[0043] S1: Take thyme grass and add ethanol water solution to decoct, add the ethanol water solution 8 times the weight of the thyme grass for the first time, heat to reflux, decoct for 1 hour, add the ethanol water solution 6 times the weight of the thyme grass for the second time, heat Reflux and decoct for 2 hours;

[0044] S2: Filter the decoction, combine the filtrates, concentrate under reduced pressure, recover ethanol until the relative density is 1.24 (80°C), and let cool;

[0045] S3: Add water 8 times the weight of Thyme chinensis to the decoction obtained in step S2, and stir well; then add water 4 times the weight of Thyme chinensis, and stir well;

[0046] S4: Stand still for 8 hours, filter the su...

Embodiment 3

[0050] Prepare the following raw materials:

[0051] Thyme 110 Kg, micronized silica gel 2 Kg, sucrose 12 Kg, dextrin 18 Kg. The particle size of the micropowdered silica gel is between 300-400 mesh.

[0052] Prepare Bairui Granules according to the following steps:

[0053] S1: Take thyme grass and add ethanol water solution to decoct, add the ethanol water solution of 7 times the weight of the thyme grass for the first time, heat to reflux, decoct for 2 hours, add the ethanol water solution of 5 times the weight of the thyme grass for the second time, and heat Reflux and decoct for 2 hours;

[0054] S2: Filter the decoction, combine the filtrates, concentrate under reduced pressure, recover ethanol until the relative density is 1.23 (80°C), and let cool;

[0055] S3: Add water 7 times the weight of Thyme chinensis to the decoction obtained in step S2, and stir well; then add water 4 times the weight of Thyme chinensis, and stir well;

[0056] S4: Stand still for 12 hours...

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Abstract

The invention provides a preparation of Bairui, in particular relates to its granule dosage form, and belongs to the technical field of traditional Chinese medicine preparations. The barley granule comprises the following raw materials in parts by weight: 100-120 parts of thyme grass, 1-3 parts of micropowder silica gel, 10-15 parts of sucrose, and 15-20 parts of dextrin. Its preparation method is obtained by wet granulation, and adopts the extraction process of first alcohol extraction and then water precipitation. The present invention improves the stability of the flavonoid active ingredients in the granule by improving the prescription and the prescription process of the Bairui granule, and at the same time reduces the friability of the granules, making the granules more stable during processing, packaging and transportation. It is stable and not easy to break; at the same time, the extraction rate of active ingredients in Thyme officinalis has been improved by improving the preparation process.

Description

technical field [0001] The invention provides a preparation of Bairui, in particular relates to its granule dosage form, and belongs to the technical field of traditional Chinese medicine preparations. Background technique [0002] Chinese herbal thyme grass (CHINSES BASTARDTOADFLAX HERB), the Chinese aliases are Lilacgrass, ground pomegranate, thin beard grass, a pine, accumulating herbs, pearl grass, Artemisia phoenix, Qinglongcao, coral grass, playing grass, stone rapeseed , Pine hair ginseng, Xiaocao and Baifengcao, etc., are collectively referred to as a variety of plant medicinal materials of the genus Thesium L. in the family Santalaceae. They are distributed in tropical and temperate regions. There are 8 species in my country, all of which are produced in all provinces; Thymus is the dried whole herb of Thyme (Thesium chinense Turcz.) or its variant T. chinense Turcz. var longipedunculatum Chu. [0003] Studies have found that thyme grass mainly contains polysacchari...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61K9/16A61K47/04A61K47/36A61K47/26A61P11/04A61P11/02A61P11/00A61P29/00
Inventor 管悦琴管习海吴兰霜
Owner 九华华源药业股份有限公司