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High-activity poultry antibody effervescent granular preparation and preparation method thereof

An effervescent granule, highly active technology, applied in the direction of antibodies, antiviral agents, medical preparations with inactive ingredients, etc., can solve the problems of inconvenience, poor palatability, high storage and transportation costs, and achieve good palatability and effect. Outstanding, simple and practical effect of preparation process

Active Publication Date: 2014-02-26
济南大东农生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention overcomes the shortcomings of existing antibody preparations such as inconvenient use, poor palatability, high storage and transportation costs, and provides a poultry antibody effervescent granule preparation and a preparation method thereof

Method used

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  • High-activity poultry antibody effervescent granular preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1: Bird flu antibody effervescent granule preparation

[0032] (1) Preparation of avian influenza egg yolk antibody powder:

[0033] 1. Weigh the lungs, spleen and liver that meet the requirements of avian influenza lesions, grind them into a homogenate with a grinder, add sterilized saline at a mass ratio of 1:5, continue to grind evenly, and then filter them with 3 layers of 140-mesh nylon filter Filter, add 0.50% formaldehyde, mix evenly, place at 37°C for 24 hours, add 2% Tween 80, mix well, check for miscellaneous bacteria with ordinary medium, and store in a cool place after passing the test;

[0034] 2. Preparation of avian influenza inactivated oil adjuvant tissue seedlings: choose No. 10 white oil, add 3% aluminum hydroxide, mix evenly, heat and fully dissolve. It is made in a 3:1 ratio with the liquid in step 1;

[0035] 3. Select healthy high-yielding laying hens without specific infectious diseases, and inject 1.5ml of avian influenza inactiva...

Embodiment 2

[0048] Example 2: Effervescent Granules of Avian Newcastle Disease Egg Yolk Antibody:

[0049] (1) Preparation of poultry Newcastle disease egg yolk antibody powder:

[0050] 1. Select SPF eggs, wash and disinfect them, and incubate them at 37.9°C for 10 days. Dilute the Newcastle disease virus seed at 1:100, inoculate the allantoic cavity of 10-day chicken embryos, 0.1ml per embryo, seal the inoculation hole, and continue to hatch;

[0051] 2. Observe in the dark room with egg lighting or microscope light, take out the dead chicken embryos (those with chicken embryos that are fixed in one place and the blood vessels dissipate and turn dark red are dead embryos), put them in the air chamber after cooling at 4°C The site was sterilized with 5% iodine, and then aseptically sucked out of the embryonic fluid;

[0052] 3. Antigen inactivation: Add 0.1% formaldehyde to the chicken embryo liquid, shake well, inactivate at 37°C for 16 hours, shake 3-5 times during the period. The c...

Embodiment 3

[0063] Example 3 Avian Influenza and Newcastle Disease Compound Antibody Effervescent Granule Preparation

[0064] Formula (parts by weight): 36 parts of avian influenza yolk antibody powder, 27 parts of Newcastle disease yolk antibody powder, 46 parts of starch and dimension powder, 10 parts of 35% ethanol solution, 15 parts of α-starch, 3 parts of sucrose, 13 parts of citric acid, 12 parts of baking soda, 0.05 part of lemon yellow, 0.01 part of caramel color, 0.02 part of creamy vanilla essence. Wherein the preparation methods of avian influenza egg yolk antibody powder and Newcastle disease egg yolk antibody powder are respectively the same as those in Examples 1-2.

[0065] 1. Grind avian influenza yolk antibody powder, Newcastle disease yolk antibody powder, starch and vitamin powder, α-starch, citric acid, and baking soda with a stainless steel universal grinder to achieve a fineness of 200 mesh, and set aside.

[0066] 2. Weigh avian influenza yolk antibody powder, New...

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Abstract

The invention discloses a high-activity poultry antibody effervescent granular preparation and a preparation method thereof. The preparation is prepared from poultry egg yolk antibody and accessory materials consisting of a carrier, a wetting agent, a binder, a thermal protective agent, a disintegrating agent, a coloring agent and a flavoring agent. In use of the poultry antibody effervescent granular preparation, the preparation can be rapidly and uniformly dissolved in a water body and gives off special fragrance inducing poultry, so sick poultry are urged to completely drink medicinal soup in a short period of time, retention time of the preparation in an in-vitro environment is reduced, rapid entering of the medicinal soup into an alimentary canal is ensured, and the utilization rate of the preparation is fully improved.

Description

technical field [0001] The invention relates to a highly active poultry antibody effervescent granule preparation and a preparation method thereof, belonging to the field of veterinary biotechnology. Background technique [0002] Avian IgY is an antibody against a specific antigen extracted from immunized poultry eggs, and is a protein with strong immune function. IgY has good stability in various environments, such as heat resistance, acid resistance, alkali resistance and enzymatic degradation resistance. IgY is resistant to repeated freezing and thawing, and experiments have shown that its antigen binding activity is hardly affected after 5 repeated freezing and thawing. Under normal circumstances, IgY can basically tolerate pasteurization, and its activity does not change significantly at 37°C. When the temperature reaches 65°C, the activity of IgY can be maintained for more than 24 h. Adding a suitable protective agent to the IgY solution can improve its thermal stab...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K39/42A61K47/36A61P31/16A61P31/14
Inventor 车建军王立明王思琪
Owner 济南大东农生物技术有限公司
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