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Novel useful active agent for preventing and/or treating dandruff on the scalp

A dandruff, scalp technology, applied in the field of new beneficial active agents for the prevention and/or treatment of dandruff conditions of the scalp, capable of solving problems such as non-adherence to treatment, slowing down of development, effects of dandruff active agents

Inactive Publication Date: 2014-02-26
LOREAL SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the aggressiveness of some anti-dandruff active agents with respect to epidermal cells or scalp bioflora can also affect the barrier function of the scalp and lead to aggravated dandruff conditions
Finally, the efficacy of anti-dandruff treatments is often slow to develop and requires rigorous application in the long term
This lag time often results in non-adherence to treatment
Therefore, many failures occur in the use of these treatments

Method used

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  • Novel useful active agent for preventing and/or treating dandruff on the scalp
  • Novel useful active agent for preventing and/or treating dandruff on the scalp
  • Novel useful active agent for preventing and/or treating dandruff on the scalp

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0168] Preparation of the active agent according to the invention

[0169] The complete fermentation medium was prepared by culturing the strain of Vitiligo linearis in its complete medium.

[0170] The initial medium used to obtain the complete fermentation medium had the composition described in Table 1 below.

[0171] Table 1

[0172] Chemical Name

[c]

Autolyzed Extract of Yeast

4g / l

[0173] Soy Papaya Peptone F

3g / l

Dextrose - Dextrose Monohydrate (Roferose)

3g / l

K H 2 PO 4

0.088g / l

CaCl 2

0.050g / l

CuSO 4 ·5H 2 o

60μg / l

MnSO 4 ·1H 2 o

152μg / l

KI

20μg / l

ZnSO 4 ·7H 2 o

200μg / l

AlCl 3 ·6H 2 o

100μg / l

seepage water

Surplus 1l

[0174] In order to obtain the cosmetic active agent according to the invention, ie in this example the lysate of Vitiligo vitratus in complete fermentation medium, the method ...

Embodiment 2

[0187] In Example 2, (i) shampoos comprising an anti-dandruff active agent according to the invention (a lysate of Vitiligo vibriella bacteria in a complete fermentation medium prepared according to Example 1) were compared Effect of formulations and (ii) reference anti-dandruff shampoo formulations without anti-dandruff active agents according to the invention and comprising conventional anti-dandruff active agents (ZnPT) on dandruff conditions of the scalp.

[0188] Therefore, the lysate of the bacteria in the complete fermentation medium (anti-dandruff active agent according to the invention) as obtained in Example 1 was used as anti-dandruff active agent in a shampoo formulation, which The basic composition of the dosage formulation is described in Table 2 below.

[0189] Several clinical studies have been conducted,

[0190] Clinical Study 1, corresponding to figure 1 ,

[0191] Clinical Study 2, corresponding to figure 2 ,

[0192] Clinical Study 3, corresponding ...

Embodiment 3

[0241] Negative MIC data for indicating no antifungal effect

[0242] The test product is exposed to the Malassezia suspension. This mixture was deposited on the surface of the agar medium. The mixture was spread out and excess mixture was recovered prior to incubation. Cultivation was continued for at least 5 days at 30°C.

[0243] Products were placed in liquid modified Leeming and Notman medium (LNm) and tested in duplicate. The complete culture is 7.5 g / l or 150 g / l (concentrated form) based on dry matter.

[0244] Complete cultures were tested at 10% (for a concentration at 7.5 g / l) and 1% (for a concentration at 150 g / l).

[0245] The positive reference was 1% zinc pyrithione.

[0246] The solution of the product was concentrated twice to allow for dilution to 1 / 2 during contact with the Malassezia suspension.

[0247] Table 8

[0248]

[0249] M. globosa and M. restrictis strains were collected on agar slants and subcultured at 30° C. and grown until tested....

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Abstract

The invention relates to a the cosmetic use of a bacterial lysate pertaining to the Vitreoscilla sp. genus (particularly the Vitreoscilla filiformis species) in a complete fermentation medium, as an active agent for preventing and / or treating dandruff on the scalp, including dandruff on the scalp associated with a prevalence of the pathogenic microorganisms on the scalp and / or an imbalance of the ecoflora of the scalp.

Description

technical field [0001] The present invention relates to the cosmetic use of active agents derived from microorganisms of the genus Vitreoscilla (especially species: Vitreoscilla filiformis) as active agents for the prevention and / or treatment of dandruff disorders of the scalp, The dandruff condition includes a dandruff condition associated with the proliferation of pathogenic microorganisms on the scalp and / or an imbalance of the ecological flora of the scalp. Background technique [0002] Skin is a tissue in which cells are connected together and integrally attached to each other. Skin tissue forms the outer layer including the sebaceous or sweat glands and hair follicles. The skin, especially the scalp, is an epidermis that undergoes continuous regeneration. Regeneration or desquamation is a coordinated and finely regulated process that results in the imperceptible and invisible removal of superficial cells. [0003] However, abnormal or irregular shedding of the cells...

Claims

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Application Information

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IPC IPC(8): A61K8/99A61Q5/00
CPCA61K2800/85A61K2800/74A61K8/99A61Q5/006A61K2800/70A61K35/74
Inventor 帕斯卡·希莱尔杨·马希理查德·马丁
Owner LOREAL SA
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