Autofluorescent fault molecular imaging equipment compatible with magnetic resonance

Abstract

The invention discloses autofluorescent fault molecular imaging equipment compatible with magnetic resonance. The autofluorescent fault molecular imaging equipment comprises optical imaging equipment and a guide rail; the optical imaging equipment comprises a shielding case and an optical camera obscura, wherein an imaging device is arranged inside the optical camera obscura; the two sides of the guide rail are located in existing medical magnetic resonance equipment and the optical imaging equipment respectively, the guide rail is provided with a carrying platform used for carrying a small animal, and the carrying platform can slide on the guide rail; the shielding case isolates mutual interference between the magnetic resonance equipment and the optical imaging equipment; the carrying platform guarantees that the small animal does not need to be hung and the posture of the small animal does not change in the magnetic resonance imaging process and the optical camera process. A two-sided reflector and rotating wheels are adopted so that the optical imaging equipment can acquire multi-angle multi-spectral autofluorescent data in one plane. High-precision three-dimensional imaging is realized based on the autofluorescent data in combination with structural data provided by the magnetic resonance equipment.

Description

technical field [0001] The present invention relates to a magnetic resonance-compatible autofluorescence tomography molecular imaging device, more specifically, it relates to a multi-spectral and multi-angle autofluorescence tomography device combined with magnetic resonance, which can realize biological internal Noninvasive real-time dynamic in vivo imaging of physiological or pathological processes. Background technique [0002] According to the concept of molecular imaging proposed by Weissleder, all biomedical imaging methods that can characterize and measure biological processes in vivo at the cellular and molecular levels belong to the category of molecular imaging. Currently common molecular imaging modalities mainly include nuclide imaging, such as positron emission tomography, single photon emission computed tomography, magnetic resonance imaging, optical imaging, and ultrasound imaging. Each modal imaging technology has its own advantages and disadvantages, and th...

AI Technical Summary

Problems solved by technology

X-rays are not very effective in soft tissue imaging, and small animals have large deformations in the hanging posture of internal organs, and insufficient single-spectrum data, all of which are detrimental to the reconstruction effect

A multi-spectral fluorescence tomographic imaging device is also disclosed in the Chinese utility model patent specification CN202568208U, which uses filters to obtain multiple fluorescent images for optical three-dimensional reconstruction, but uses a frontal single-angle optical signal, and does not provide Imaging with other modalities to provide tissue architecture for 3D reconstruction

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