Anti-tumor application of 3-{2-[([1,1'-biphenyl]-4-methyl)amino]-1-ethoxy}phenol

A hydroxyethyl, anti-tumor drug technology, applied in the fields of biotechnology and medicine, can solve the problems of high production costs and achieve the effect of inhibiting the growth of liver cancer cells

Active Publication Date: 2014-03-12
FOURTH MILITARY MEDICAL UNIVERSITY
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At present, there are no small molecule drugs and candidate compounds targeting HAb18G/CD147. The "Iodine [131I] Metuximab Injection" targeting HAb18G/CD147 has b

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  • Anti-tumor application of 3-{2-[([1,1'-biphenyl]-4-methyl)amino]-1-ethoxy}phenol
  • Anti-tumor application of 3-{2-[([1,1'-biphenyl]-4-methyl)amino]-1-ethoxy}phenol
  • Anti-tumor application of 3-{2-[([1,1'-biphenyl]-4-methyl)amino]-1-ethoxy}phenol

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[0025] The present invention will be further described in detail below in conjunction with the accompanying drawings and specific experimental results. This section is only for illustrating the present invention and is not intended to limit the scope of the present invention. Experimental methods that do not indicate specific conditions are generally in accordance with conventional conditions, such as those described in "Molecular Cloning: A Laboratory Manual" (New York, Cold Spring Harbor Laboratory Press, New York: Cold Spring Harbor Laboratory Press, 1989) by Sambrook et al. above conditions, or as recommended by the manufacturer.

[0026] Unless otherwise defined, all professional and scientific terms used in the present invention have the same meanings that are familiar to those skilled in the art. The preferred implementation methods and materials described below are for demonstration purposes only.

[0027]After extensive and in-depth research in the early stage, it w...

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Abstract

The invention discloses an anti-tumor application of 3-{2-[([1,1'-biphenyl]-4-methyl)amino]-1-ethoxy}phenol. The 3-{2-[([1,1'-biphenyl]-4-methyl)amino]-1-ethoxy}phenol low molecular weight compound is screened out through a candidate medicine screening platform combining structural biology, bioinformatics and biology activity testing and can be applied to the anti-tumor field, or is combined with other medicines or means so as to be applied to the anti-tumor field. The 3-{2-[([1,1'-biphenyl]-4-methyl)amino]-1-ethoxy}phenol can be used for the targeted inhibition of HAb18G/CD147 protein and can be applied in the preparation of medicines for treating diseases related to HAb18G/CD147 protein high expression (such as tumors, especially liver cancer).

Description

technical field [0001] The invention belongs to the fields of biotechnology and medicine, and specifically relates to the antitumor application of 3-{2-[([1,1'-biphenyl]-4-methyl)amino]-1-hydroxyethyl}phenol. Background technique [0002] Liver cancer is one of the diseases that seriously threaten human life and health, and the mortality rate is extremely high. Currently, the common methods of treatment for liver cancer are surgery, radiotherapy and chemotherapy. However, most patients have already entered the advanced stage when they go to the doctor, and are not suitable for surgical resection, and the long-term curative effect of radiotherapy and chemotherapy is also poor. In recent years, with the continuous development of modern molecular biology and proteomics, molecular targeted therapy of liver cancer has gradually emerged, and has attracted widespread attention and great attention. Molecular targeted therapy is to target the specific molecular markers of liver can...

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Application Information

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IPC IPC(8): A61K31/137A61P35/00
Inventor 陈志南付之光蒋建利朱平崔洪勇彭建龙汪莉
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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