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Method for producing demeclocycline hydrochloride by utilizing demeclocycline fermentation broth

A technology of demethylaureomycin hydrochloride and demethylaureomycin, which is applied in the field of producing demethylaureomycin hydrochloride, can solve the problems of not being suitable for industrialized large-scale production, long extraction process cycle, and easy emulsification, etc., and achieves easy operation , shorten the extraction production cycle, and improve work efficiency

Active Publication Date: 2015-01-07
宁夏泰瑞制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] 1) Organic solvents (including ethyl acetate and butyl acetate) are used in the production process, the solvent consumption is large, and the generated wastewater contains organic solvents, which is easy to pollute the environment
[0006] 2) The traditional extraction process has a long period, exceeding 70h
[0007] 3) The extraction yield is low, generally around 85%
[0008]4) Emulsification is prone to occur during the extraction process
[0009]5) Higher production costs
[0010] The second technique is to extract demethylaureomycin by column chromatography purification method, but this method is suitable for sample laboratory testing and is not suitable for industrialized large-scale production, which will easily lead to a series of problems such as low product yield and high production cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The mixing speed is 10R / min, the de -norroticin fermentation solution will be 1m 3 (Value: 12435mg / L) The temperature is increased to 80 ° C, then settled for 20 minutes, and cooled to room temperature.Add 1kg polyacrylamide, set up 70 minutes, add 1kg of industrial oxalic acid, continue to stir up for 50 minutes, and then filter with stainless steel metal mesh. The filtering accuracy of the stainless steel metal mesh is 400 μm to obtain nortomycin filter fluid.After filtering the stainless steel metal mesh, the norrocyromycin residue was washed twice with a drinking water roof with pH 3.40%of the weight, a hydrochloric acid regulating pH with a mass concentration of 20%.End of the pre -processing, get 0.96m of the filter fluid 3 The cost of filtrate is 12246mg / L, and the income yield is 94.5%.

[0038] Before the membrane was filtered, the viscosity of the norvyromycin filtrate with purified water was 3912CPS.The temperature of the filtrate is controlled at 30 ~ 32 ℃, and ...

Embodiment 2

[0044] The mixing speed is 15R / min, 1m will be removed from the norvyromycin fermentation solution 3(Value: 12324mg / L) The temperature is increased to 85 ° C, and then settled for 25 minutes to cool to room temperature.Add 1.5kg to gather amine, static for 75 minutes, add 2kg of sodium oxalic acid, continue to stand for 70min, and then filter with stainless steel metal mesh. The filtering accuracy of the stainless steel metal mesh is 420 μm to obtain the norroticinicillin filter fluid.After filtering the stainless steel metal mesh, the norrocyromycin residue was washed 2 times with a drink with pH with a pH of 3.5.42%of the weight, using a concentration of 22%hydrochloric acid regulating pH.End of the pre -processing, get 0.98M 3 The cost of filtrate is 11909mg / L, and the yield is 94.7%.

[0045] Before the membrane was filtered, the viscosity of the norvyromycin filtrate with purified water was 3903CPS.The temperature of the filtrate is controlled at 32 to 34 ° C and the pressure...

Embodiment 3

[0051] The mixing speed is 20r / min, the de -A funderromycin fermentation solution is 1m 3 (Value: 12284mg / L) The temperature increases to 90 ° C, and then static for 30 minutes to cool down to room temperature.Add 2kg to gather amine, static for 80 minutes, add 3kg of sodium oxalate, continue to stir up for 55 minutes, and then filter with stainless steel metal mesh. The filtering accuracy of the stainless steel metal mesh is 450 μm to obtain nortomycin filter fluid.After filtering the stainless steel metal mesh, the norrocyromycin residue was washed twice with a drinking water roof with pH 4.45%of the weight, using a concentration of 25%hydrochloric acid regulating pH.End of the pre -processing, get 1M 3 , The cost of filtrate is 11682mg / L, and the yield is 95.1%.

[0052] Before the membrane was filtered, the viscosity of the norvyromycin filtrate with purified water was 3854CPS.The temperature of the filtrate is controlled at 34 to 36 ° C and the pressure is controlled at 1 to ...

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Abstract

The invention relates to a method for producing demeclocycline hydrochloride by utilizing a demeclocycline fermentation broth. The method comprises that thedemeclocycline hydrochloride is obtained by performing pretreatment, tubular porous ceramics membrane filtration, dilution nanofiltration, crystal water washing, acid-base neutralization, ultrafiltration and spray drying on the demeclocycline fermentation broth. The method helps to realize stable efficient production of a bulk drug demeclocycline hydrochloride. Also the method helps to simplify the extraction technology of demeclocycline, improve the extraction yield of demeclocycline salts, shorten production period, reduce cost and improve demeclocycline yield, and has the advantages of being energy-saving, capable of reducing environmental pollution, simple in operation, high in work efficiency and the like.

Description

Technical field [0001] The present invention belongs to the field of antibiotic extraction and synthetic technology, especially the method of using the use of norvyromycin fermentation liquid to produce hydrochloride hydrochloric acid. Background technique [0002] Pharine -hydrochloride is also known as plactinicin, de -niche chloride tetracycline, nominomycin, etc., which are fermented with golden chain mold.Meticillin is the secondary metabolic product of chaincin, which is mainly used for the production of Mino cycloin and alfalfa.Its antibacteriality is strong, the antibacterial spectrum is similar to ristomycin, its effect is stronger than tetrain and omotin, and stable than ristomycin. It is a derivative product of tetracycline antibiotics. [0003] At present, according to relevant literature reports, there are two main types of production processes to extract raw materials to A fundedin salt. [0004] The first process is mainly to remove the main problems of salt produc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C237/26C07C231/24
CPCY02P20/10
Inventor 任勇
Owner 宁夏泰瑞制药股份有限公司