Novel mouse nerve growth factor intravitreal injection drug delivery system and application thereof

A technology of nerve growth factor and drug delivery system, which is applied in the direction of nervous system diseases, cardiovascular system diseases, preparations for in vivo experiments, etc., can solve the problems of large side effects and unsatisfactory treatment effects, and achieve effective treatment and reduce systemic Toxic and side effects, the effect of reducing the blinding rate

Inactive Publication Date: 2014-03-26
黄丽娜
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0006] Aiming at the problems of unsatisfactory therapeutic effect and large side effects in the existing administration methods of mouse nerve growth factor for treating eye diseases mentioned in the background technology, the object of the present invention is to provide a system for int

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  • Novel mouse nerve growth factor intravitreal injection drug delivery system and application thereof
  • Novel mouse nerve growth factor intravitreal injection drug delivery system and application thereof
  • Novel mouse nerve growth factor intravitreal injection drug delivery system and application thereof

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Embodiment Construction

[0017] The present invention will be described in further detail below in conjunction with the accompanying drawings and specific embodiments. The following embodiments are explanations of the present invention, and the present invention is not limited to the following embodiments.

[0018] Drugs for intravitreal injection of mouse nerve growth factor:

[0019] A Stable Suspension of Sulfur Hexafluoride Microbubbles and Mouse Nerve Growth Factor 1:1 Dissolved in Physiological Saline

[0020] The method of administering the above drugs via intravitreal injection:

[0021] Topical anesthesia with alcaine eye drops and mydriasis with compound tropicamide eye drops. Under the operating microscope, a proper amount of aqueous humor is extracted from the transparent corneal area at the upper corneoscleral limbus by tunnel puncture, and the upper corneoscleral limbus is 3mm Insert the needle vertically into the sclera and penetrate into the vitreous cavity. After the dilated pupil is...

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Abstract

The inventions discloses a novel mouse nerve growth factor intravitreal injection drug delivery system and an application thereof, and relates to the field of mouse nerve growth factor-containing drug for treating oculopathy through intravitreal injection drug delivery. In allusion to the problems that non-ideal treatment effect and big side effects existing in a conventional drug delivery mode of a mouse nerve growth factor for treating oculopathy, the invention aims to provide the mouse nerve growth factor intravitreal injection drug delivery system which is characterized by comprising the mouse nerve growth factor and an ultrasonic contrast agent. The invention also provides the application of the mouse nerve growth factor intravitreal injection drug delivery system in preparing a drug for treating glaucomatous optic nerve damage, wherein the drug is used for being administrated by intravitreal injection under ultrasonic irradiation. The novel drug delivery mode provided by the invention has the advantages of good treatment effect, safety and reliability, and can be used for delaying or preventing occurrence and development of the glaucomatous optic nerve damage.

Description

technical field [0001] The invention relates to the field of medicine containing mouse nerve growth factor which can be administered through vitreous cavity injection to treat eye diseases. Background technique [0002] Nerve Growth Factor (NGF) is the first neurotrophic factor discovered and the most thoroughly researched at present. It is a nerve cell growth regulator with dual biological functions of neuron nutrition and neurite growth. The development, differentiation, growth, regeneration and expression of functional properties of peripheral neurons all play important regulatory roles. It can be used clinically to treat eye diseases caused by optic nerve damage. [0003] Mouse nerve growth factor (mNGF) is an intramuscular injection NGF extracted from the submandibular gland of mice. It is a national Class I new drug with a purity of more than 98%. It has a high degree of homology with human NGF structure and has no obvious biological effects. Species (human versus mo...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61K49/22A61P27/02A61P27/06A61P25/00A61P9/10
CPCA61K9/0048A61K38/185A61K49/223A61P9/10A61P25/00A61P27/02A61P27/06
Inventor 黄丽娜申晓丽马大卉赵军赖铭莹
Owner 黄丽娜
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