Novel mouse nerve growth factor intravitreal injection drug delivery system and application thereof

Abstract

The inventions discloses a novel mouse nerve growth factor intravitreal injection drug delivery system and an application thereof, and relates to the field of mouse nerve growth factor-containing drug for treating oculopathy through intravitreal injection drug delivery. In allusion to the problems that non-ideal treatment effect and big side effects existing in a conventional drug delivery mode of a mouse nerve growth factor for treating oculopathy, the invention aims to provide the mouse nerve growth factor intravitreal injection drug delivery system which is characterized by comprising the mouse nerve growth factor and an ultrasonic contrast agent. The invention also provides the application of the mouse nerve growth factor intravitreal injection drug delivery system in preparing a drug for treating glaucomatous optic nerve damage, wherein the drug is used for being administrated by intravitreal injection under ultrasonic irradiation. The novel drug delivery mode provided by the invention has the advantages of good treatment effect, safety and reliability, and can be used for delaying or preventing occurrence and development of the glaucomatous optic nerve damage.

Description

technical field [0001] The invention relates to the field of medicine containing mouse nerve growth factor which can be administered through vitreous cavity injection to treat eye diseases. Background technique [0002] Nerve Growth Factor (NGF) is the first neurotrophic factor discovered and the most thoroughly researched at present. It is a nerve cell growth regulator with dual biological functions of neuron nutrition and neurite growth. The development, differentiation, growth, regeneration and expression of functional properties of peripheral neurons all play important regulatory roles. It can be used clinically to treat eye diseases caused by optic nerve damage. [0003] Mouse nerve growth factor (mNGF) is an intramuscular injection NGF extracted from the submandibular gland of mice. It is a national Class I new drug with a purity of more than 98%. It has a high degree of homology with human NGF structure and has no obvious biological effects. Species (human versus mo...

AI Technical Summary

Problems solved by technology

[0006] Aiming at the problems of unsatisfactory therapeutic effect and large side effects in the existing administration methods of mouse nerve growth factor for treating eye diseases mentioned in the background technology, the object of the present invention is to provide a system for intravitreal injection of mouse nerve growth factor, To break the existing way of drug administration, and to treat eye diseases by injecting mouse nerve growth factor into the vitreous cavity, this new way of drug delivery has the advantages of good therapeutic effect, safety and reliability

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