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Triterpenoid compounds and application thereof in diabetes treatment drugs

A compound and drug technology, applied in the field of biomedicine, can solve the problems of high adverse reactions and weak activity, and achieve the effect of good α-glucosidase inhibitory activity, small molecular weight, and low dosage

Active Publication Date: 2014-03-26
HANGZHOU HUADONG MEDICINE GRP PHARMA RES INST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims to overcome the defects of weak activity and high adverse reactions of current α-glucosidase-targeted diabetes drugs, and provides two compounds with strong α-glucosidase inhibitory activity

Method used

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  • Triterpenoid compounds and application thereof in diabetes treatment drugs
  • Triterpenoid compounds and application thereof in diabetes treatment drugs
  • Triterpenoid compounds and application thereof in diabetes treatment drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] The preparation method of embodiment 1 compound 1 and 2

[0048] 1. Preparation of Inonotus obliquus fermentation product by fermentation culture

[0049] 1), strains:

[0050] Inonotus obliquus is classified as Fuscoporia obliqua (Pers: Fr.) Aoshima, and is preserved by the China Agricultural Microorganism Culture Collection and Management Center, and the strain number is 1511C0001ACCC51184.

[0051] 2) Cultivation and preservation of seed strains

[0052]Solid medium: glucose 3g, potato extract powder 0.5g, KH2PO40.2g, soybean peptone 0.5g, agar 1.5g, add water to 100mL, adjust pH to 6.0.

[0053] Solid culture method: the strain is inoculated on a solid medium slant and cultured at 28°C for 7-10 days.

[0054] After the solid culture is over, place the slant at 4-10°C and refrigerate for later use.

[0055] 3) Shake flask seed culture

[0056] Medium: glucose 3g, yeast extract powder 1.0g, soybean peptone 1.0g, KH2PO 40.2g, add water to 100mL, adjust pH to 6.0. ...

Embodiment 2

[0075] Embodiment 2: Physicochemical properties and spectral data of compound 1

[0076]

[0077] Compound 1: white amorphous powder; molecular formula is C 31 h 46 o 3 ;Optical rotation [α] 20 D +70.5(c0.088, CHCl 3 ); Infrared (KBr)ν max 3567, 2964, 2928, 1714, 1185, 1125cm -1 ; Hydrogen spectrum and carbon spectrum (CDCl 3 ,500MHz) See Table 1 Mass Spectrum (ESI) m / z: 467[M+H] + .

Embodiment 3

[0078] Embodiment 3: Physicochemical properties and spectral data of compound 2

[0079]

[0080] Compound 2: white amorphous powder; molecular formula is C 31 h 48 o 3 ;Optical rotation [α] 20 D +100.0(c0.19, CHCl 3 ); Infrared (KBr)ν max 3418,2934,1662,1595,1517,1458,1417,1189,1042,675cm -1 ; Hydrogen spectrum and carbon spectrum (CDCl 3 ,500MHz) See Table 1 Mass Spectrum (ESI) m / z: 469[M+H] + .

[0081] Table 1 NMR data of compounds 1 and 2

[0082]

[0083]

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PUM

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Abstract

The invention relates to two new triterpenoid compounds which are derived frominonotus obliquus leavening matters, have strong alpha-glycosidase inhibition activity, and can be used for the preparation of diabetes treatment drugs. The present invention also discloses a preparation method of the two new compounds and pharmaceutical compositions.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a new triterpene compound and its application in medicine for treating diabetes. Background technique [0002] Diabetes mellitus is a metabolic disease characterized by hyperglycemia caused by defects in insulin secretion or its biological action. The long-term high blood sugar in diabetes leads to chronic damage and dysfunction of various tissues, especially the eyes, kidneys, heart, blood vessels, and nerves. The mild ones cause various chronic diseases or physical disabilities in the human body, and the severe ones cause death. With the continuous development of human civilization, people in society no longer have to worry about food and clothing, and the calorie intake through food is gradually increasing. At the same time, the improvement of working conditions has gradually reduced the calorie consumption of the body. Therefore, the incidence of diabetes in many count...

Claims

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Application Information

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IPC IPC(8): C07J17/00C12P33/20A61K31/585A61P3/10C12R1/645
Inventor 占扎君白海波张霞单伟光
Owner HANGZHOU HUADONG MEDICINE GRP PHARMA RES INST
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